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- W1978049553 abstract "Synchronous fluorescence (SF) is used to study structurally and spectrally similar anthracycline anti-tumor drugs in biological fluids and model membranes. SF bandwidths at half maxima are typically 20-24 nm versus 75-80 nm for unresolved spectra acquired during conventional scans. This substantial band-narrowing effect permits excellent resolution between Adriamycin and an interferant, 5- iminodaunorubicin, in a two-component mixture. SF detection limits for Adriamycin are 7 x 10-7 M in serum and 1.5 x 10-7 M in buffered aqueous solution. Additional studies of structurally homologous drugs in liposomes and organic solvents indicate that SF may be useful in characterizing the influence of substituent groups on relative membrane permeation depth." @default.
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- W1978049553 date "1989-05-17" @default.
- W1978049553 modified "2023-09-23" @default.
- W1978049553 title "Synchronous Fluorescence Studies Of Anthracycline Anti-Tumor Drugs" @default.
- W1978049553 doi "https://doi.org/10.1117/12.951552" @default.
- W1978049553 hasPublicationYear "1989" @default.
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