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- W1978049582 abstract "Funding sources: none. Conflicts of interest: none declared. Dear Editor, Buprenorphine is a partial opioid agonist used as an oral maintenance treatment for opioid dependence, as a high‐dose formulation. The branded form of high‐dose buprenorphine (HDB) – Subutex® – was introduced in France in 1996. Several generic drugs have been marketed since then. HDB has become the first oral maintenance treatment for opioid dependence in France. However, the generalization of HDB has led to its misuse.1 2 Misuse of HDB injections is responsible for serious locoregional complications and represents a worrying public health concern. In France the national monitoring system of drug dependence and misuse falls under the responsibility of the French National Agency for Medicines and Health Products Safety. In order to carry out this monitoring, the agency relies on a network of 13 regional Centres for Evaluation and Information on Pharmacodependence (CEIP).3 In 2011, the CEIP of Nantes was notified of unusual cutaneous complications among injecting HDB users. French health authorities decided to implement a specific and prospective national case collection of these cutaneous complications. The CEIP of Nantes was responsible for coordinating this investigation." @default.
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- W1978049582 date "2015-03-09" @default.
- W1978049582 modified "2023-10-14" @default.
- W1978049582 title "Livedo-like dermatitis and necrotic lesions after high-dose buprenorphine injections: a national French survey" @default.
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- W1978049582 doi "https://doi.org/10.1111/bjd.13503" @default.
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