FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978049658> ?p ?o ?g. }

• W1978049658 endingPage "72" @default.
• W1978049658 startingPage "67" @default.
• W1978049658 abstract "The acute administration of MDMA has been shown to promote glycogenolysis and increase the extracellular concentration of glucose in the striatum. In the present study the role of serotonergic and/or noradrenergic mechanisms in the MDMA-induced increase in extracellular glucose and glycogenolysis was assessed. The relationship of these responses to the hyperthermia produced by MDMA also was examined. The administration of MDMA (10 mg/kg, i.p.) resulted in a significant and sustained increase of 65–100% in the extracellular concentration of glucose in the striatum, as well as in the prefrontal cortex and hippocampus, and a 35% decrease in brain glycogen content. Peripheral blood glucose was modestly increased by 32% after MDMA treatment. Treatment of rats with fluoxetine (10 mg/kg, i.p.) significantly attenuated the MDMA-induced increase in extracellular glucose in the striatum but had no effect on MDMA-induced glycogenolysis or hyperthermia. Treatment with prazosin (1 mg/kg, i.p.) did not alter the glucose or glycogen responses to MDMA but completely suppressed MDMA-induced hyperthermia. Finally, propranolol (3 mg/kg, i.p.) significantly attenuated the MDMA-induced increase in extracellular glucose and glycogenolysis but did not alter MDMA-induced hyperthermia. The present results suggest that MDMA increases extracellular glucose in multiple brain regions, and that this response involves both serotonergic and noradrenergic mechanisms. Furthermore, β-adrenergic and α-adrenergic receptors appear to contribute to MDMA-induced glycogenolysis and hyperthermia, respectively. Finally, hyperthermia, glycogenolysis and elevated extracellular glucose appear to be independent, unrelated responses to acute MDMA administration." @default.
• W1978049658 created "2016-06-24" @default.
• W1978049658 creator A5029513865 @default.
• W1978049658 creator A5050938986 @default.
• W1978049658 creator A5056962301 @default.
• W1978049658 creator A5088401686 @default.
• W1978049658 date "2010-10-01" @default.
• W1978049658 modified "2023-09-26" @default.
• W1978049658 title "Role of serotonin and/or norepinephrine in the MDMA-induced increase in extracellular glucose and glycogenolysis in the rat brain" @default.
• W1978049658 cites W1899272159 @default.
• W1978049658 cites W1966155265 @default.
• W1978049658 cites W1976956499 @default.
• W1978049658 cites W1983947475 @default.
• W1978049658 cites W1987507203 @default.
• W1978049658 cites W1997210023 @default.
• W1978049658 cites W2000574341 @default.
• W1978049658 cites W2006073621 @default.
• W1978049658 cites W2009328760 @default.
• W1978049658 cites W2011320995 @default.
• W1978049658 cites W2015485611 @default.
• W1978049658 cites W2023585901 @default.
• W1978049658 cites W2025746567 @default.
• W1978049658 cites W2026835867 @default.
• W1978049658 cites W2031099959 @default.
• W1978049658 cites W2034109798 @default.
• W1978049658 cites W2036829402 @default.
• W1978049658 cites W2045897942 @default.
• W1978049658 cites W2050415436 @default.
• W1978049658 cites W2054897143 @default.
• W1978049658 cites W2057528351 @default.
• W1978049658 cites W2061489773 @default.
• W1978049658 cites W2067092746 @default.
• W1978049658 cites W2078704741 @default.
• W1978049658 cites W2082383749 @default.
• W1978049658 cites W2083687710 @default.
• W1978049658 cites W2092166671 @default.
• W1978049658 cites W2120113858 @default.
• W1978049658 cites W2124714506 @default.
• W1978049658 cites W2163259434 @default.
• W1978049658 cites W2164216920 @default.
• W1978049658 cites W2395252678 @default.
• W1978049658 doi "https://doi.org/10.1016/j.ejphar.2010.07.004" @default.
• W1978049658 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2944403" @default.
• W1978049658 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20633550" @default.
• W1978049658 hasPublicationYear "2010" @default.
• W1978049658 type Work @default.
• W1978049658 sameAs 1978049658 @default.
• W1978049658 citedByCount "13" @default.
• W1978049658 countsByYear W19780496582012 @default.
• W1978049658 countsByYear W19780496582013 @default.
• W1978049658 countsByYear W19780496582014 @default.
• W1978049658 countsByYear W19780496582015 @default.
• W1978049658 countsByYear W19780496582018 @default.
• W1978049658 countsByYear W19780496582019 @default.
• W1978049658 countsByYear W19780496582020 @default.
• W1978049658 crossrefType "journal-article" @default.
• W1978049658 hasAuthorship W1978049658A5029513865 @default.
• W1978049658 hasAuthorship W1978049658A5050938986 @default.
• W1978049658 hasAuthorship W1978049658A5056962301 @default.
• W1978049658 hasAuthorship W1978049658A5088401686 @default.
• W1978049658 hasBestOaLocation W19780496582 @default.
• W1978049658 hasConcept C126322002 @default.
• W1978049658 hasConcept C134018914 @default.
• W1978049658 hasConcept C170493617 @default.
• W1978049658 hasConcept C185592680 @default.
• W1978049658 hasConcept C2775864247 @default.
• W1978049658 hasConcept C2777499176 @default.
• W1978049658 hasConcept C2777949327 @default.
• W1978049658 hasConcept C2779949491 @default.
• W1978049658 hasConcept C2780062018 @default.
• W1978049658 hasConcept C2780876324 @default.
• W1978049658 hasConcept C28406088 @default.
• W1978049658 hasConcept C37000724 @default.
• W1978049658 hasConcept C50156730 @default.
• W1978049658 hasConcept C513476851 @default.
• W1978049658 hasConcept C55493867 @default.
• W1978049658 hasConcept C71924100 @default.
• W1978049658 hasConcept C98274493 @default.
• W1978049658 hasConceptScore W1978049658C126322002 @default.
• W1978049658 hasConceptScore W1978049658C134018914 @default.
• W1978049658 hasConceptScore W1978049658C170493617 @default.
• W1978049658 hasConceptScore W1978049658C185592680 @default.
• W1978049658 hasConceptScore W1978049658C2775864247 @default.
• W1978049658 hasConceptScore W1978049658C2777499176 @default.
• W1978049658 hasConceptScore W1978049658C2777949327 @default.
• W1978049658 hasConceptScore W1978049658C2779949491 @default.
• W1978049658 hasConceptScore W1978049658C2780062018 @default.
• W1978049658 hasConceptScore W1978049658C2780876324 @default.
• W1978049658 hasConceptScore W1978049658C28406088 @default.
• W1978049658 hasConceptScore W1978049658C37000724 @default.
• W1978049658 hasConceptScore W1978049658C50156730 @default.
• W1978049658 hasConceptScore W1978049658C513476851 @default.
• W1978049658 hasConceptScore W1978049658C55493867 @default.
• W1978049658 hasConceptScore W1978049658C71924100 @default.
• W1978049658 hasConceptScore W1978049658C98274493 @default.
• W1978049658 hasIssue "1-3" @default.
• W1978049658 hasLocation W19780496581 @default.
• W1978049658 hasLocation W19780496582 @default.

• next