FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978055376> ?p ?o ?g. }

• W1978055376 endingPage "498" @default.
• W1978055376 startingPage "491" @default.
• W1978055376 abstract "Numerous studies have focused on the regulation of leptin signalling and the functions of leptin in energy homoeostasis; however, little is known about how leptin secretion is regulated. In the present study we studied leptin storage and secretion regulation in 3T3-L1 and primary adipocytes. Leptin is stored in membrane-bound vesicles that are localized predominantly in the ER (endoplasmic reticulum) and close to the plasma membrane of both 3T3-L1 and primary adipocytes. Insulin increases leptin secretion as early as 15 min without affecting the leptin mRNA level. Interestingly, treatment with the protein synthesis inhibitor cycloheximide and the ER–Golgi trafficking blocker Brefeldin A inhibit both basal and ISLS (insulin-stimulated leptin secretion), suggesting that insulin stimulates leptin secretion by up-regulating leptin synthesis and that leptin-containing vesicles go through the ER–Golgi route. The PI3K (phosphoinositide 3-kinase)/Akt, but not MAPK (mitogen-activated protein kinase), pathway is involved in ISLS in vitro and in vivo. Although Ca2+ triggers synaptic vesicle and secretory granule exocytosis, Ca2+ influx alone is not sufficient to induce leptin secretion. Remarkably, Ca2+ is required for ISLS possibly due to its involvement in insulin-stimulated Akt phosphorylation. We conclude that insulin stimulates leptin release through the PI3K/Akt pathway and that Ca2+ is required for robust Akt phosphorylation and leptin secretion." @default.
• W1978055376 created "2016-06-24" @default.
• W1978055376 creator A5014023198 @default.
• W1978055376 creator A5020211628 @default.
• W1978055376 creator A5033632697 @default.
• W1978055376 creator A5084146581 @default.
• W1978055376 creator A5088726345 @default.
• W1978055376 creator A5090243523 @default.
• W1978055376 date "2014-02-28" @default.
• W1978055376 modified "2023-09-26" @default.
• W1978055376 title "Insulin-stimulated leptin secretion requires calcium and PI3K/Akt activation" @default.
• W1978055376 cites W1933726946 @default.
• W1978055376 cites W1976974669 @default.
• W1978055376 cites W1977746407 @default.
• W1978055376 cites W1982602254 @default.
• W1978055376 cites W1987613834 @default.
• W1978055376 cites W1988642574 @default.
• W1978055376 cites W1993484144 @default.
• W1978055376 cites W1993836723 @default.
• W1978055376 cites W1996713062 @default.
• W1978055376 cites W2003012378 @default.
• W1978055376 cites W2007638416 @default.
• W1978055376 cites W2011823591 @default.
• W1978055376 cites W2032840486 @default.
• W1978055376 cites W2038654585 @default.
• W1978055376 cites W2039331449 @default.
• W1978055376 cites W2053635222 @default.
• W1978055376 cites W2060682066 @default.
• W1978055376 cites W2063162657 @default.
• W1978055376 cites W2064778017 @default.
• W1978055376 cites W2066427930 @default.
• W1978055376 cites W2067643705 @default.
• W1978055376 cites W2078332130 @default.
• W1978055376 cites W2088986234 @default.
• W1978055376 cites W2089788793 @default.
• W1978055376 cites W2104053160 @default.
• W1978055376 cites W2104255063 @default.
• W1978055376 cites W2116072037 @default.
• W1978055376 cites W2126095470 @default.
• W1978055376 cites W2138304893 @default.
• W1978055376 cites W2276776369 @default.
• W1978055376 cites W2317051542 @default.
• W1978055376 doi "https://doi.org/10.1042/bj20131176" @default.
• W1978055376 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24405299" @default.
• W1978055376 hasPublicationYear "2014" @default.
• W1978055376 type Work @default.
• W1978055376 sameAs 1978055376 @default.
• W1978055376 citedByCount "43" @default.
• W1978055376 countsByYear W19780553762014 @default.
• W1978055376 countsByYear W19780553762015 @default.
• W1978055376 countsByYear W19780553762016 @default.
• W1978055376 countsByYear W19780553762017 @default.
• W1978055376 countsByYear W19780553762018 @default.
• W1978055376 countsByYear W19780553762019 @default.
• W1978055376 countsByYear W19780553762020 @default.
• W1978055376 countsByYear W19780553762021 @default.
• W1978055376 countsByYear W19780553762022 @default.
• W1978055376 countsByYear W19780553762023 @default.
• W1978055376 crossrefType "journal-article" @default.
• W1978055376 hasAuthorship W1978055376A5014023198 @default.
• W1978055376 hasAuthorship W1978055376A5020211628 @default.
• W1978055376 hasAuthorship W1978055376A5033632697 @default.
• W1978055376 hasAuthorship W1978055376A5084146581 @default.
• W1978055376 hasAuthorship W1978055376A5088726345 @default.
• W1978055376 hasAuthorship W1978055376A5090243523 @default.
• W1978055376 hasConcept C11960822 @default.
• W1978055376 hasConcept C126322002 @default.
• W1978055376 hasConcept C134018914 @default.
• W1978055376 hasConcept C14372207 @default.
• W1978055376 hasConcept C158617107 @default.
• W1978055376 hasConcept C175969161 @default.
• W1978055376 hasConcept C185592680 @default.
• W1978055376 hasConcept C2779306644 @default.
• W1978055376 hasConcept C2780613262 @default.
• W1978055376 hasConcept C49039625 @default.
• W1978055376 hasConcept C511355011 @default.
• W1978055376 hasConcept C62478195 @default.
• W1978055376 hasConcept C71924100 @default.
• W1978055376 hasConcept C75217442 @default.
• W1978055376 hasConcept C86554907 @default.
• W1978055376 hasConcept C86803240 @default.
• W1978055376 hasConcept C95444343 @default.
• W1978055376 hasConceptScore W1978055376C11960822 @default.
• W1978055376 hasConceptScore W1978055376C126322002 @default.
• W1978055376 hasConceptScore W1978055376C134018914 @default.
• W1978055376 hasConceptScore W1978055376C14372207 @default.
• W1978055376 hasConceptScore W1978055376C158617107 @default.
• W1978055376 hasConceptScore W1978055376C175969161 @default.
• W1978055376 hasConceptScore W1978055376C185592680 @default.
• W1978055376 hasConceptScore W1978055376C2779306644 @default.
• W1978055376 hasConceptScore W1978055376C2780613262 @default.
• W1978055376 hasConceptScore W1978055376C49039625 @default.
• W1978055376 hasConceptScore W1978055376C511355011 @default.
• W1978055376 hasConceptScore W1978055376C62478195 @default.
• W1978055376 hasConceptScore W1978055376C71924100 @default.
• W1978055376 hasConceptScore W1978055376C75217442 @default.
• W1978055376 hasConceptScore W1978055376C86554907 @default.
• W1978055376 hasConceptScore W1978055376C86803240 @default.

• next