Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978055574> ?p ?o ?g. }
- W1978055574 endingPage "427" @default.
- W1978055574 startingPage "420" @default.
- W1978055574 abstract "To develop an optimized simvastatin (SV) delivery device for bone regeneration, SV-loaded poly(ethylene glycol)-poly(ε-caprolactone) (PECL) micelles were constructed. The micelles had an average size of 80 nm. The in vitro release behavior of SV from the micelles showed prolonged release compared to the free SV. The following four groups were tested in a cytologic experiment: a free SV group, a SV-loaded micelle group with SV concentrations ranging from 2.5×10(-6) to 2.5×10(-10) M, a drug-free micelle group and a blank control group. The effect of SV-loaded micelles on osteoblast-like MG-63 cells was determined via analysis of cell proliferation, alkaline phosphatase activity, and cell calcification. In addition, the mRNA and protein expression of the BMP-2 gene were determined with real-time fluorescence quantitative polymerase chain reaction and western blot techniques, respectively. The results show that SV-loaded PECL micelles cause effective suppression of the osteoblast early proliferation inhibition, stimulation of osteoblast differentiation and mineralization, and stimulation of the BMP-2 expression. Therefore, SV-loaded PECL micelles are predicted to have great potential in bone regeneration applications." @default.
- W1978055574 created "2016-06-24" @default.
- W1978055574 creator A5004102712 @default.
- W1978055574 creator A5007321108 @default.
- W1978055574 creator A5041215420 @default.
- W1978055574 creator A5049091841 @default.
- W1978055574 creator A5051366494 @default.
- W1978055574 creator A5056787291 @default.
- W1978055574 creator A5074047906 @default.
- W1978055574 creator A5078690279 @default.
- W1978055574 creator A5079073938 @default.
- W1978055574 creator A5080089101 @default.
- W1978055574 creator A5086574130 @default.
- W1978055574 date "2013-02-01" @default.
- W1978055574 modified "2023-10-02" @default.
- W1978055574 title "Effects of simvastatin-loaded polymeric micelles on human osteoblast-like MG-63 cells" @default.
- W1978055574 cites W1973096997 @default.
- W1978055574 cites W1974816188 @default.
- W1978055574 cites W1983223375 @default.
- W1978055574 cites W1987498988 @default.
- W1978055574 cites W1987986587 @default.
- W1978055574 cites W1988672795 @default.
- W1978055574 cites W2004259371 @default.
- W1978055574 cites W2009005190 @default.
- W1978055574 cites W2009709078 @default.
- W1978055574 cites W2015680138 @default.
- W1978055574 cites W2020364703 @default.
- W1978055574 cites W2021214738 @default.
- W1978055574 cites W2021438186 @default.
- W1978055574 cites W2027267703 @default.
- W1978055574 cites W2031010510 @default.
- W1978055574 cites W2034387263 @default.
- W1978055574 cites W2034824405 @default.
- W1978055574 cites W2040156285 @default.
- W1978055574 cites W2040500601 @default.
- W1978055574 cites W2045211074 @default.
- W1978055574 cites W2045997611 @default.
- W1978055574 cites W2049320871 @default.
- W1978055574 cites W2056454438 @default.
- W1978055574 cites W2066781262 @default.
- W1978055574 cites W2091576875 @default.
- W1978055574 cites W2096738462 @default.
- W1978055574 cites W2117599170 @default.
- W1978055574 cites W2157388990 @default.
- W1978055574 cites W2163887121 @default.
- W1978055574 cites W2164947608 @default.
- W1978055574 doi "https://doi.org/10.1016/j.colsurfb.2012.06.037" @default.
- W1978055574 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23006576" @default.
- W1978055574 hasPublicationYear "2013" @default.
- W1978055574 type Work @default.
- W1978055574 sameAs 1978055574 @default.
- W1978055574 citedByCount "30" @default.
- W1978055574 countsByYear W19780555742013 @default.
- W1978055574 countsByYear W19780555742014 @default.
- W1978055574 countsByYear W19780555742015 @default.
- W1978055574 countsByYear W19780555742016 @default.
- W1978055574 countsByYear W19780555742017 @default.
- W1978055574 countsByYear W19780555742018 @default.
- W1978055574 countsByYear W19780555742019 @default.
- W1978055574 countsByYear W19780555742020 @default.
- W1978055574 countsByYear W19780555742021 @default.
- W1978055574 countsByYear W19780555742022 @default.
- W1978055574 countsByYear W19780555742023 @default.
- W1978055574 crossrefType "journal-article" @default.
- W1978055574 hasAuthorship W1978055574A5004102712 @default.
- W1978055574 hasAuthorship W1978055574A5007321108 @default.
- W1978055574 hasAuthorship W1978055574A5041215420 @default.
- W1978055574 hasAuthorship W1978055574A5049091841 @default.
- W1978055574 hasAuthorship W1978055574A5051366494 @default.
- W1978055574 hasAuthorship W1978055574A5056787291 @default.
- W1978055574 hasAuthorship W1978055574A5074047906 @default.
- W1978055574 hasAuthorship W1978055574A5078690279 @default.
- W1978055574 hasAuthorship W1978055574A5079073938 @default.
- W1978055574 hasAuthorship W1978055574A5080089101 @default.
- W1978055574 hasAuthorship W1978055574A5086574130 @default.
- W1978055574 hasConcept C104317684 @default.
- W1978055574 hasConcept C11268172 @default.
- W1978055574 hasConcept C12554922 @default.
- W1978055574 hasConcept C134018914 @default.
- W1978055574 hasConcept C153911025 @default.
- W1978055574 hasConcept C160160445 @default.
- W1978055574 hasConcept C178790620 @default.
- W1978055574 hasConcept C181199279 @default.
- W1978055574 hasConcept C184651966 @default.
- W1978055574 hasConcept C185592680 @default.
- W1978055574 hasConcept C202751555 @default.
- W1978055574 hasConcept C24998067 @default.
- W1978055574 hasConcept C2776329913 @default.
- W1978055574 hasConcept C2776415932 @default.
- W1978055574 hasConcept C2777516009 @default.
- W1978055574 hasConcept C2778260815 @default.
- W1978055574 hasConcept C30352789 @default.
- W1978055574 hasConcept C55493867 @default.
- W1978055574 hasConcept C86803240 @default.
- W1978055574 hasConcept C98274493 @default.
- W1978055574 hasConceptScore W1978055574C104317684 @default.
- W1978055574 hasConceptScore W1978055574C11268172 @default.
- W1978055574 hasConceptScore W1978055574C12554922 @default.