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• W1978061745 abstract "The purpose of the present study was to analyze the influence of stress (24-h cold exposure) on presynaptic 5-HT 1A receptors, and on postsynaptic 5-HT 1A , 5-HT 1C and 5-HT 2 receptors. Cold exposure for 24 h affected neither pargyline-induced decreases in 5-hydroxyindoleacetic acid (5-HIAA) levels in midbrain and rest of brain, nor plasma glucose and corticosterone levels. Treatment with the 5-HT 1A receptor agonist, 8-hydroxy-2(di-n-propylamino)tetralin (8-OH-DPAT; 0.5–1 mg/kg), 3–5 h after the end of cold exposure triggered less intense flat body posture and forepaw treading in cold-exposed rats than in controls. On the other hand, 15- and 30-min plasma glucose responses to 8-OH-DPAT (0.25–0.5 mg/kg, 3–5 h after cold) or to the α 2 -adrenoceptor agonist, clonidine (0.025 mg/kg), were not affected by cold, while the 15-min, but not the 30 min, plasma corticosterone response to 8-OH-DPAT was slightly amplified in cold-exposed rats. Cold exposure affected neither the inhibitory effect of 8-OH-DPAT (0.25–0.5 mg/kg, 3–5 h after cold) on midbrain 5-HIAA levels, nor the hypothermic effect of 8-OH-DPAT (0.5–1 mg/kg, 3–5 h after cold). Lastly, the hypoactivity elicited by the 5-HT 1C recepor agonist, m-chlorophenyl-piperazine (1.5–3 mg/kg, 3–5 h after cold), or head shakes elicited by the 5-HT 2 receptor agonist, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (1–2 mg/kg, 3–5 h after cold), were of similar intensities in control and in cold-exposed rats." @default.
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• W1978061745 date "1992-08-01" @default.
• W1978061745 modified "2023-09-27" @default.
• W1978061745 title "Effects of cold stress on some 5-HT1A, 5-HT1C and 5-HT2 receptor-mediated responses" @default.
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• W1978061745 doi "https://doi.org/10.1016/0014-2999(92)90304-m" @default.
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