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• W1978062012 abstract "Significance The P-element–induced wimpy testis (PIWI) proteins and their bound small RNAs (PIWI-interacting RNAs, piRNAs) are known to repress transposon expression in the germline, yet they likely have broader regulatory functions. We show that the PIWI–piRNA pathway functions in the stem cells of an early diverging animal. We demonstrate that Hydra has two PIWI proteins that are localized in the cytoplasm of all adult stem/progenitor cell types. We identified putative targets of the pathway, both transposon and nontransposon, by sequencing piRNAs and mapping them to a newly assembled Hydra transcriptome. Finally we demonstrate that Hydra PIWI is essential in the somatic lineages. This study supports the existence of a common regulatory pathway ancestral to both stem and germ cells." @default.
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• W1978062012 date "2013-12-23" @default.
• W1978062012 modified "2023-10-11" @default.
• W1978062012 title "PIWI proteins and PIWI-interacting RNAs function in <i>Hydra</i> somatic stem cells" @default.
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• W1978062012 doi "https://doi.org/10.1073/pnas.1320965111" @default.
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