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W1978073047 endingPage "2318" @default.
W1978073047 startingPage "2289" @default.
W1978073047 abstract "Trans-plasma membrane electron transport (t-PMET) has been established since the 1960s, but it has only been subject to more intensive research in the last decade. The discovery and characterization at the molecular level of its novel components has increased our understanding of how t-PMET regulates distinct cellular functions. This review will give an update on t-PMET, with particular emphasis on how its malfunction relates to some diseases, such as cancer, abnormal cell death, cardiovascular diseases, aging, obesity, neurodegenerative diseases, pulmonary fibrosis, asthma, and genetically linked pathologies. Understanding these relationships may provide novel therapeutic approaches for pathologies associated with unbalanced redox state. Antioxid. Redox Signal. 14, 2289–2318. Introduction Measurements of Electron-Transfer Reactions Components of the t-PMET Electron donors Electron acceptors Intermediate electron carriers Enzymes NADPH oxidases Structure and mechanism of action (1) Nox 1–4 (2) Nox5 (2) Duox 1–2 Biological functions NAD(P)H:quinone oxidoreductase 1 Structure and mechanism of action Biological functions Disulfide-thiol exchangers Structure and mechanism of action Biological functions Voltage-dependent anion-selective channels Structure and mechanism of action Biological functions Duodenal cytochrome b Structure and mechanism of action Biological functions Cytochrome b5 reductase Structure and mechanism of action Biological functions Physiological Roles of t-PMET Proton pumping Sperm maturation and fertilization Blood redox homeostasis Platelet physiology Autophagy Antibody control Pathological Roles of t-PMET Apoptosis Cancer Cardiovascular diseases Aging Obesity, metabolic syndrome, and diabetes Neurodegenerative diseases Pulmonary fibrosis Asthma Conclusions" @default.
W1978073047 created "2016-06-24" @default.
W1978073047 creator A5002844341 @default.
W1978073047 creator A5003335216 @default.
W1978073047 creator A5013730845 @default.
W1978073047 creator A5063616237 @default.
W1978073047 date "2011-06-01" @default.
W1978073047 modified "2023-09-30" @default.
W1978073047 title "Trans-Plasma Membrane Electron Transport in Mammals: Functional Significance in Health and Disease" @default.
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