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• W1978084992 abstract "<i>Background:</i> Experimental data suggest that high-grade vascular stenosis may induce chronic cerebral tissue damage. <i>Methods:</i> We tested this hypothesis in 97 patients with a ≧70% unilateral internal carotid artery (ICA) stenosis (mean age: 69.1 ± 10.2 years), comparing intraindividual side-to-side differences in hemispheric brain and white matter hyperintensity (WMH) volumes. Patients with a supratentorial infarct exceeding 1.5 cm in diameter were excluded. <i>Results:</i> Overall, the median WMH volume was greater in the hemisphere ipsilateral to the stenotic ICA (1.13 ± 2.65 vs. 0.77 ± 2.26 cm³; p = 0.005), but there were no differences in hemispheric brain volumes between the stenotic and nonstenotic sides. In the subgroup of patients with moderate and severe WMH (n = 41), the hemispheric volume ipsilateral to the stenotic ICA was significantly smaller (543.46 ± 22.17 vs. 548.66 ± 26.7 cm³; p = 0.03). Multivariate linear regression analysis revealed an independent effect of WMH grade on interhemispheric volume differences relative to the side of stenosis. <i>Conclusions:</i> Chronic tissue damage may occur in a subset of individuals with ≧70% ICA stenosis, globally exhibiting more extensive WMH." @default.
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• W1978084992 date "2010-01-01" @default.
• W1978084992 modified "2023-10-16" @default.
• W1978084992 title "High-Grade Internal Carotid Artery Stenosis and Chronic Brain Damage: A Volumetric Magnetic Resonance Imaging Study" @default.
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• W1978084992 doi "https://doi.org/10.1159/000319025" @default.
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