FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978093992> ?p ?o ?g. }

• W1978093992 endingPage "46" @default.
• W1978093992 startingPage "39" @default.
• W1978093992 abstract "Neuronal responses to alcohol involve several hormone- and neurotransmitter-activated signal transduction pathways. Recent studies suggest that the adenosine A2 receptor (A2) mediates important actions of alcohol. Ethanol inhibits adenosine reuptake, increases extracellular adenosine, and promotes activation of A2. This leads to enhanced cAMP/protein kinase A (PKA) signaling ranging from increases in cAMP to stimulation of cAMP-dependent cAMP response element (CRE)-mediated gene expression. Medium spiny neurons in the striatum/nucleus accumbens (NAc) express A2 and dopamine D2 receptor (D2) on the same cells. Studies in model neuronal cell lines and primary neurons in culture expressing A2 and D2 provide evidence for synergy between ethanol/A2 and D2. Subthreshold concentrations of ethanol or a D2 agonist, without effect separately, synergistically activate cAMP/PKA signaling. Thus, neurons expressing A2 and D2 on the same cells, like in the NAc, are characterized by hypersensitivity to ethanol with a simultaneous activation of dopaminergic signaling. Synergy requires adenosine and appears to be mediated by the release of free betagamma dimers from G(i/o) via D2 activation. The release of free betagamma has pathophysiological significance in the drinking animal because specific blockade of betagamma signaling in the NAc strikingly reduces voluntary alcohol consumption. These findings suggest that signaling pathways, which regulate synergy between A2 and D2, might contain molecular targets for the prevention and treatment of alcoholism and alcohol abuse." @default.
• W1978093992 created "2016-06-24" @default.
• W1978093992 creator A5006183635 @default.
• W1978093992 creator A5021896989 @default.
• W1978093992 date "2004-01-01" @default.
• W1978093992 modified "2023-10-10" @default.
• W1978093992 title "Recent advances in the neurobiology of alcoholism: the role of adenosine" @default.
• W1978093992 cites W1490848194 @default.
• W1978093992 cites W1497441168 @default.
• W1978093992 cites W1497625469 @default.
• W1978093992 cites W1551550807 @default.
• W1978093992 cites W1576286569 @default.
• W1978093992 cites W1604214492 @default.
• W1978093992 cites W1837235659 @default.
• W1978093992 cites W1969583788 @default.
• W1978093992 cites W1974463013 @default.
• W1978093992 cites W1975319708 @default.
• W1978093992 cites W1977731479 @default.
• W1978093992 cites W1981480470 @default.
• W1978093992 cites W1990186184 @default.
• W1978093992 cites W1994764392 @default.
• W1978093992 cites W1995566206 @default.
• W1978093992 cites W1997586459 @default.
• W1978093992 cites W1998529957 @default.
• W1978093992 cites W2000648746 @default.
• W1978093992 cites W2002927748 @default.
• W1978093992 cites W2004556707 @default.
• W1978093992 cites W2008590959 @default.
• W1978093992 cites W2010696255 @default.
• W1978093992 cites W2011275122 @default.
• W1978093992 cites W2012419419 @default.
• W1978093992 cites W2015311494 @default.
• W1978093992 cites W2018884476 @default.
• W1978093992 cites W2020821105 @default.
• W1978093992 cites W2023080349 @default.
• W1978093992 cites W2026795314 @default.
• W1978093992 cites W2035141753 @default.
• W1978093992 cites W2038858164 @default.
• W1978093992 cites W2041843111 @default.
• W1978093992 cites W2043083570 @default.
• W1978093992 cites W2045223441 @default.
• W1978093992 cites W2049796382 @default.
• W1978093992 cites W2056564132 @default.
• W1978093992 cites W2058730899 @default.
• W1978093992 cites W2061473590 @default.
• W1978093992 cites W2061562817 @default.
• W1978093992 cites W2067467266 @default.
• W1978093992 cites W2068108933 @default.
• W1978093992 cites W2072707718 @default.
• W1978093992 cites W2073561633 @default.
• W1978093992 cites W2074247654 @default.
• W1978093992 cites W2074484901 @default.
• W1978093992 cites W2084043489 @default.
• W1978093992 cites W2095352917 @default.
• W1978093992 cites W2105737054 @default.
• W1978093992 cites W2108005833 @default.
• W1978093992 cites W2108445291 @default.
• W1978093992 cites W2116251096 @default.
• W1978093992 cites W2125916741 @default.
• W1978093992 cites W2128693499 @default.
• W1978093992 cites W2136306454 @default.
• W1978093992 cites W2145758516 @default.
• W1978093992 cites W2145832086 @default.
• W1978093992 cites W2156823117 @default.
• W1978093992 cites W2159634179 @default.
• W1978093992 cites W2160146943 @default.
• W1978093992 cites W2162348868 @default.
• W1978093992 cites W2593766363 @default.
• W1978093992 cites W4254566369 @default.
• W1978093992 cites W4300672705 @default.
• W1978093992 cites W4321429580 @default.
• W1978093992 doi "https://doi.org/10.1016/j.pharmthera.2003.10.002" @default.
• W1978093992 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14729391" @default.
• W1978093992 hasPublicationYear "2004" @default.
• W1978093992 type Work @default.
• W1978093992 sameAs 1978093992 @default.
• W1978093992 citedByCount "95" @default.
• W1978093992 countsByYear W19780939922012 @default.
• W1978093992 countsByYear W19780939922013 @default.
• W1978093992 countsByYear W19780939922014 @default.
• W1978093992 countsByYear W19780939922015 @default.
• W1978093992 countsByYear W19780939922016 @default.
• W1978093992 countsByYear W19780939922017 @default.
• W1978093992 countsByYear W19780939922018 @default.
• W1978093992 countsByYear W19780939922019 @default.
• W1978093992 countsByYear W19780939922021 @default.
• W1978093992 countsByYear W19780939922022 @default.
• W1978093992 countsByYear W19780939922023 @default.
• W1978093992 crossrefType "journal-article" @default.
• W1978093992 hasAuthorship W1978093992A5006183635 @default.
• W1978093992 hasAuthorship W1978093992A5021896989 @default.
• W1978093992 hasConcept C104317684 @default.
• W1978093992 hasConcept C134018914 @default.
• W1978093992 hasConcept C1629964 @default.
• W1978093992 hasConcept C169760540 @default.
• W1978093992 hasConcept C170493617 @default.
• W1978093992 hasConcept C184235292 @default.
• W1978093992 hasConcept C185592680 @default.

• next