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- W1978101850 abstract "The development of novel immune-based therapeutics for neurodegenerative diseases is an area of intense focus. Neurodegenerative diseases represent a particular challenge since in many cases the onset of symptoms occurs after considerable degeneration has ensued. Based on human genetic and histopathological evidence from patients with neurodegenerative diseases, animal models that recapitulate specific pathologic features have been developed. Utilizing these animal models in combination with viral vector-based gene therapeutics, specific epochs of disease can be targeted. One common feature of several neurodegenerative diseases is misfolded proteins. The mechanism by which these altered protein conformers lead to neurodegeneration is not completely understood but much effort has been put forward to either degrade aberrant protein or prevent the formation of misfolded conformers. In this review, we will summarize work that employs viral vector gene therapeutics to modulate the brain's response to misfolded proteins with a specific focus on neurodegeneration." @default.
- W1978101850 created "2016-06-24" @default.
- W1978101850 creator A5003466529 @default.
- W1978101850 creator A5069458729 @default.
- W1978101850 date "2008-10-18" @default.
- W1978101850 modified "2023-09-28" @default.
- W1978101850 title "Immune-Directed Gene Therapeutic Development for Alzheimer’s, Prion, and Parkinson’s Diseases" @default.
- W1978101850 cites W1482580692 @default.
- W1978101850 cites W1521854746 @default.
- W1978101850 cites W1527671059 @default.
- W1978101850 cites W1528113046 @default.
- W1978101850 cites W1550083773 @default.
- W1978101850 cites W1567490604 @default.
- W1978101850 cites W1609471181 @default.
- W1978101850 cites W1621971853 @default.
- W1978101850 cites W1630502818 @default.
- W1978101850 cites W1693283493 @default.
- W1978101850 cites W1705725530 @default.
- W1978101850 cites W1964576814 @default.
- W1978101850 cites W1965275873 @default.
- W1978101850 cites W1966019489 @default.
- W1978101850 cites W1967549235 @default.
- W1978101850 cites W1968788087 @default.
- W1978101850 cites W1968849614 @default.
- W1978101850 cites W1968990406 @default.
- W1978101850 cites W1969349734 @default.
- W1978101850 cites W1973418987 @default.
- W1978101850 cites W1974924674 @default.
- W1978101850 cites W1976110439 @default.
- W1978101850 cites W1977002082 @default.
- W1978101850 cites W1978525961 @default.
- W1978101850 cites W1978633824 @default.
- W1978101850 cites W1991989649 @default.
- W1978101850 cites W1993801613 @default.
- W1978101850 cites W1994067502 @default.
- W1978101850 cites W2000397440 @default.
- W1978101850 cites W2000917982 @default.
- W1978101850 cites W2001210466 @default.
- W1978101850 cites W2001382455 @default.
- W1978101850 cites W2002497988 @default.
- W1978101850 cites W2002520289 @default.
- W1978101850 cites W2002778911 @default.
- W1978101850 cites W2003456064 @default.
- W1978101850 cites W2004875827 @default.
- W1978101850 cites W2007093034 @default.
- W1978101850 cites W2007689996 @default.
- W1978101850 cites W2009174342 @default.
- W1978101850 cites W2009556855 @default.
- W1978101850 cites W2012961210 @default.
- W1978101850 cites W2016777985 @default.
- W1978101850 cites W2021356347 @default.
- W1978101850 cites W2021897883 @default.
- W1978101850 cites W2024356065 @default.
- W1978101850 cites W2025730665 @default.
- W1978101850 cites W2027535761 @default.
- W1978101850 cites W2029205666 @default.
- W1978101850 cites W2034743023 @default.
- W1978101850 cites W2037194302 @default.
- W1978101850 cites W2041888108 @default.
- W1978101850 cites W2042811786 @default.
- W1978101850 cites W2043551476 @default.
- W1978101850 cites W2045062740 @default.
- W1978101850 cites W2045776001 @default.
- W1978101850 cites W2047885160 @default.
- W1978101850 cites W2049334534 @default.
- W1978101850 cites W2050786534 @default.
- W1978101850 cites W2052093243 @default.
- W1978101850 cites W2052151366 @default.
- W1978101850 cites W2052825194 @default.
- W1978101850 cites W2055609315 @default.
- W1978101850 cites W2056213354 @default.
- W1978101850 cites W2063909850 @default.
- W1978101850 cites W2068602144 @default.
- W1978101850 cites W2069095254 @default.
- W1978101850 cites W2076413927 @default.
- W1978101850 cites W2077044335 @default.
- W1978101850 cites W2079461108 @default.
- W1978101850 cites W2080751623 @default.
- W1978101850 cites W2084972185 @default.
- W1978101850 cites W2086683565 @default.
- W1978101850 cites W2087389265 @default.
- W1978101850 cites W2088866871 @default.
- W1978101850 cites W2089207317 @default.
- W1978101850 cites W2089900719 @default.
- W1978101850 cites W2096860145 @default.
- W1978101850 cites W2098306153 @default.
- W1978101850 cites W2100298346 @default.
- W1978101850 cites W2104214286 @default.
- W1978101850 cites W2104635218 @default.
- W1978101850 cites W2107434243 @default.
- W1978101850 cites W2108728836 @default.
- W1978101850 cites W2113443121 @default.
- W1978101850 cites W2114699984 @default.
- W1978101850 cites W2120412340 @default.
- W1978101850 cites W2120997873 @default.
- W1978101850 cites W2122529630 @default.
- W1978101850 cites W2122564376 @default.
- W1978101850 cites W2124220488 @default.