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- W1978103137 abstract "Novel biodegradable, positively charged, brushlike branched polyesters, namely, poly[vinyl-3-(dialkylamino)alkylcarbamate-co-vinyl acetate-co-vinyl alcohol]-graft-poly(d,l-lactide-co-glycolide), abbreviated as (P[VACB0-70−VAc0-36−VA15-195−VPLGA75-240]), were synthesized using water-soluble amine-modified poly(vinyl alcohol) backbones in a ring opening polymerization as a platform for parenteral delivery systems of hydrophilic macromolecular drug substances such as proteins and DNA. The structure of theses graft-polyesters was studied by NMR. Modifying side chain length and charge ratio, the solubility of the polymers could be designed to range between water-soluble and lipophilic behavior. The polymers' compact, branched architecture and their molecular mass were determined by GPC-MALLS. By differential scanning calorimetry (DSC) and wide-angle X-ray scattering (WAXS) the amorphous character of the polyesters was demonstrated. The amphiphilic nature of the polyesters allowed drug entrapment by electrostatic interactions as a function of amine modification. Amine-modified graft-polyesters were shown to possess unusually short degradation times and merit further investigation as a platform for biodegradable delivery systems." @default.
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- W1978103137 date "2006-01-28" @default.
- W1978103137 modified "2023-10-16" @default.
- W1978103137 title "Biodegradable Brushlike Branched Polyesters Containing a Charge-Modified Poly(vinyl alcohol) Backbone as a Platform for Drug Delivery Systems: Synthesis and Characterization" @default.
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- W1978103137 doi "https://doi.org/10.1021/ma051837n" @default.
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