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- W1978103717 abstract "Human immunodeficiency virus type 1 (HIV-1) and pathogenic simian immunodeficiency virus (SIV)-infected naïve hosts experience a characteristic absence of early and potent virus-specific neutralizing antibody (NAb) responses preceding establishment of persistent infection. Yet conversely, we have recently shown that NAbs passively immunized in rhesus macaques at early post-SIV challenge are capable of playing a critical role in non-sterile viremia control with implications of antibody-enhanced antigen presentation. In a current follow-up study we have further reported that NAbs mediate rapid elicitation of polyfunctional virus-specific CD4+ T-cells in vivo. The NAb-immunized macaques mounting these responses exhibited sustained viremia control for over 1 year, accompanied with robust anti-SIV cellular immunity. Perspectives obtained from the results are discussed." @default.
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- W1978103717 date "2010-05-01" @default.
- W1978103717 modified "2023-10-01" @default.
- W1978103717 title "Neutralizing antibodies in SIV control: Co-impact with T cells" @default.
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- W1978103717 doi "https://doi.org/10.1016/j.vaccine.2009.09.080" @default.
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