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- W1978109712 endingPage "97" @default.
- W1978109712 startingPage "85" @default.
- W1978109712 abstract "Early and specific tumor detection and also therapy selection and response evaluation are some challenges of personalized medicine. This calls for high sensitive and specific molecular imaging such as positron emission tomography (PET). The use of peptides for PET molecular imaging has undeniable advantages: possibility of targeting through peptide-receptor interaction, small size and low-molecular weight conferring good penetration in the tissue or at cellular level, low toxicity, no antigenicity, and possibility of wide choice for radiolabeling. Among β+-emitter radioelements, Gallium-68 is a very attractive positron-emitter compared with carbon-11 or fluorine-18 taking into account its easy production via a 68Ge/68Ga generator and well established radiochemistry. Gallium-68 chemistry is based on well-defined coordination complexes with macrocycle or chelates having strong binding properties, particularly suitable for linking peptides that allow resistance to in vivo transchelation of the metal ion. Understanding specific and nonspecific molecular mechanisms involved in oncogenesis is one major key to develop new molecular imaging tools. The present review focuses on peptide signaling involved in different oncogenic pathways. This peptide signalization might be common for tumoral and non-tumoral processes or could be specific of an oncological process. This review describes gallium chemistry and different 68Ga-radiolabeled peptides already in use or under development aiming at developing molecular PET imaging of different oncological processes." @default.
- W1978109712 created "2016-06-24" @default.
- W1978109712 creator A5022699290 @default.
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- W1978109712 creator A5044191666 @default.
- W1978109712 creator A5052150943 @default.
- W1978109712 creator A5060235809 @default.
- W1978109712 date "2013-03-01" @default.
- W1978109712 modified "2023-09-26" @default.
- W1978109712 title "Gallium-68: Chemistry and Radiolabeled Peptides Exploring Different Oncogenic Pathways" @default.
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