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- W1978113495 abstract "Colorectal cancer (CRC), one of the most prevalent neoplasias in the western world, is treatable if detected early. Unfortunately, existing biomarkers such as carcinoembryonic antigen (CEA) suffer from poor sensitivity and selectivity when used for early detection, hence have limited practicality therein. To avoid difficulties associated with direct analysis of blood, studies aimed towards discovery of better early-stage markers recently targeted cancer-secreted proteins as these proteins are hypothesized to move into the bloodstream 1 . Selection of suitable candidates for further evaluation among identified secreted proteins remains a challenge as name and function of a protein do not necessarily indicate its usefulness as a marker. To identify potential biomarkers for CRC we developed an approach where we ranked all proteins identified in the secretome from five different CRC cell lines according to criteria such as tissue specificity, detection across CRC lines or relationship to cancer. To avoid detection of abundant cytoplasmic proteins derived from cell lysis we employed our recently developed hydrazide-capture method targeting glycoproteins 2 . Detection of CEA was used as a positive control and the top-ranking proteins were considered for further clinical evaluation. Proof of concept studies were conducted in mice carrying xenografts and involved analysis of proteins secreted from xenografted tumours into tumour interstitial fluid and mouse blood." @default.
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- W1978113495 date "2008-07-01" @default.
- W1978113495 modified "2023-10-18" @default.
- W1978113495 title "Detection of Biomarkers for Colorectal Cancer by Ranking of Soluble-Secreted Proteins (RSSP)" @default.
- W1978113495 doi "https://doi.org/10.4172/jpb.s1000080" @default.
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