Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978118511> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W1978118511 abstract "Pathophysiologic changes induced by phospholipase A2 (PLA2), a lipolytic enzyme implicated in a variety of pulmonary diseases, were examined in the isolated, perfused guinea pig lung. Thirty microliters of vehicle (saline) or 30 units of PLA2 suspended in saline was given as a bolus injection into either the trachea or pulmonary artery, and the lungs were examined by combined light and transmission electron microscopy at 1, 10, and 30 min following administration. Pulmonary morphologic and physiologic changes were observed only in animals that received PLA2 via the trachea. Initially, morphologic evidence of airway constriction was accompanied by a significant increase in intratracheal pressure. No morphologic change was observed in alveolar parenchymal cell populations at this time. Later there was marked swelling of airway epithelial cells accompanied by pronounced blebbing of the apical cytoplasm with a subsequent decrease in airway lumen size. Interalveolar septa were multifocally thickened by edema and alveolar spaces contained sparse fibrogranular material 10 min after intratracheal PLA2. Significant increases in lung weight were observed at this time. Morphologic features of vasoconstriction, characterized by undulating and convoluted endothelium with prominent cytoplasmic processes resulting in decreased luminal size were observed in small caliber vessels and occurred in conjunction with significant increases in pulmonary arterial pressure. There was pronounced injury to type I alveolar epithelium, including marked cell swelling and fragmentation, accompanied by lesser injury in type II alveolar epithelium. This study demonstrates that the airway epithelium was the initial cell population having morphologic change following intratracheal PLA2, and that the airway epithelium and type I alveolar epithelium were the cell populations most severely affected following intratracheal PLA2. Results further suggest that normal circulating levels of blood-formed elements are not essential for the development of PLA2-induced morphologic change in the isolated, perfused guinea pig lung." @default.
- W1978118511 created "2016-06-24" @default.
- W1978118511 creator A5034287604 @default.
- W1978118511 creator A5051007613 @default.
- W1978118511 date "1990-01-01" @default.
- W1978118511 modified "2023-09-25" @default.
- W1978118511 title "Pathophysiologic Changes Induced by Phospholipase A2in the Isolated, Perfused Guinea Pig Lung" @default.
- W1978118511 cites W1983859155 @default.
- W1978118511 cites W1989675515 @default.
- W1978118511 cites W1999494984 @default.
- W1978118511 cites W2017199104 @default.
- W1978118511 cites W2080258840 @default.
- W1978118511 cites W2081059755 @default.
- W1978118511 cites W2110119404 @default.
- W1978118511 cites W2265143763 @default.
- W1978118511 cites W2341659856 @default.
- W1978118511 cites W2410299282 @default.
- W1978118511 cites W2412282104 @default.
- W1978118511 doi "https://doi.org/10.3109/01902149009108848" @default.
- W1978118511 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2394200" @default.
- W1978118511 hasPublicationYear "1990" @default.
- W1978118511 type Work @default.
- W1978118511 sameAs 1978118511 @default.
- W1978118511 citedByCount "5" @default.
- W1978118511 crossrefType "journal-article" @default.
- W1978118511 hasAuthorship W1978118511A5034287604 @default.
- W1978118511 hasAuthorship W1978118511A5051007613 @default.
- W1978118511 hasConcept C105702510 @default.
- W1978118511 hasConcept C105922876 @default.
- W1978118511 hasConcept C126322002 @default.
- W1978118511 hasConcept C131631996 @default.
- W1978118511 hasConcept C134018914 @default.
- W1978118511 hasConcept C142724271 @default.
- W1978118511 hasConcept C2776468924 @default.
- W1978118511 hasConcept C2776992346 @default.
- W1978118511 hasConcept C2777397205 @default.
- W1978118511 hasConcept C2777714996 @default.
- W1978118511 hasConcept C2778815084 @default.
- W1978118511 hasConcept C2779644171 @default.
- W1978118511 hasConcept C2780886150 @default.
- W1978118511 hasConcept C2909420118 @default.
- W1978118511 hasConcept C42219234 @default.
- W1978118511 hasConcept C529295009 @default.
- W1978118511 hasConcept C534529494 @default.
- W1978118511 hasConcept C71924100 @default.
- W1978118511 hasConcept C86803240 @default.
- W1978118511 hasConcept C87568996 @default.
- W1978118511 hasConceptScore W1978118511C105702510 @default.
- W1978118511 hasConceptScore W1978118511C105922876 @default.
- W1978118511 hasConceptScore W1978118511C126322002 @default.
- W1978118511 hasConceptScore W1978118511C131631996 @default.
- W1978118511 hasConceptScore W1978118511C134018914 @default.
- W1978118511 hasConceptScore W1978118511C142724271 @default.
- W1978118511 hasConceptScore W1978118511C2776468924 @default.
- W1978118511 hasConceptScore W1978118511C2776992346 @default.
- W1978118511 hasConceptScore W1978118511C2777397205 @default.
- W1978118511 hasConceptScore W1978118511C2777714996 @default.
- W1978118511 hasConceptScore W1978118511C2778815084 @default.
- W1978118511 hasConceptScore W1978118511C2779644171 @default.
- W1978118511 hasConceptScore W1978118511C2780886150 @default.
- W1978118511 hasConceptScore W1978118511C2909420118 @default.
- W1978118511 hasConceptScore W1978118511C42219234 @default.
- W1978118511 hasConceptScore W1978118511C529295009 @default.
- W1978118511 hasConceptScore W1978118511C534529494 @default.
- W1978118511 hasConceptScore W1978118511C71924100 @default.
- W1978118511 hasConceptScore W1978118511C86803240 @default.
- W1978118511 hasConceptScore W1978118511C87568996 @default.
- W1978118511 hasLocation W19781185111 @default.
- W1978118511 hasLocation W19781185112 @default.
- W1978118511 hasOpenAccess W1978118511 @default.
- W1978118511 hasPrimaryLocation W19781185111 @default.
- W1978118511 hasRelatedWork W1602554333 @default.
- W1978118511 hasRelatedWork W1906157100 @default.
- W1978118511 hasRelatedWork W2059732900 @default.
- W1978118511 hasRelatedWork W2110707896 @default.
- W1978118511 hasRelatedWork W2118212157 @default.
- W1978118511 hasRelatedWork W2129363868 @default.
- W1978118511 hasRelatedWork W2162868360 @default.
- W1978118511 hasRelatedWork W2554115911 @default.
- W1978118511 hasRelatedWork W3023637149 @default.
- W1978118511 hasRelatedWork W2399031994 @default.
- W1978118511 isParatext "false" @default.
- W1978118511 isRetracted "false" @default.
- W1978118511 magId "1978118511" @default.
- W1978118511 workType "article" @default.