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• W1978122760 endingPage "488" @default.
• W1978122760 startingPage "471" @default.
• W1978122760 abstract "The effects and interactions of aging and hypertension on the myocardium were studied in spontaneously hypertensive (SHR) and normotensive (WKY) rats. Cardiac hypertrophy developed in SHR during the first 7 months of life and was initially more marked in the subendocardium than in the subepicardium. Capillary density decreased in proportion to cellular enlargement but became normalized between 7 and 15 months when cell size no longer increased, suggesting a proliferation of capillaries during this time period. Between 15 and 22 to 23 months significant cellular enlargement occurred in both SHR and WKY despite the fact that blood pressure levels were not changed. Stereological analysis showed that mitochondria/myofibrils volume ratio in SHR decreased during the development of hypertrophy, continued to decrease as hypertrophy stabilized, but normalized during senescence. Residual bodies (lipofuscin granules), characteristic of aging in myocardial cells, accumulated more markedly in SHR than in WKY. Certain other focal alterations which also are associated with aging, i.e. cell membrane invaginations and increased numbers of caveolae, appeared earlier and became more widespread in SHR. In addition, long-term hypertension elicited alterations which were not associated with aging (honey-combed t-tubules, and mitochondrial and myofibril degeneration). These data provide evidence for three conclusions regarding cardiac hypertrophy and hypertension, and aging in SHR. First, changes which are inevitable with aging are accentuated. Second, certain ultrastructural changes appear to be related to long-term hypertension rather than to the natural aging process. Finally, the relationship between the volumes of contractile and energy producing organelles is modified by factors which are not clearly related to either aging or hypertrophy and hypertension." @default.
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• W1978122760 date "1981-05-01" @default.
• W1978122760 modified "2023-10-15" @default.
• W1978122760 title "The effects of long-term pressure-overload and aging on the myocardium" @default.
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• W1978122760 doi "https://doi.org/10.1016/0022-2828(81)90264-9" @default.
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