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• W1978134798 abstract "Abstract: Cerebrovascular deposition of the amyloid beta-protein (Aβ) is a common pathologic event in patients with Alzheimer's disease (AD) and certain related disorders. Such an Aβ vascular deposition occurs primarily in the medial layer of the cerebral vessel wall in an assembled fibrillar state. These deposits are associated with several pathological responses, including degeneration of the smooth muscle cells in the cerebral vessel wall. Severe cases of cerebrovascular Aβ deposition are also accompanied by loss of vessel wall integrity and hemorrhagic stroke. Although the reasons for this pathological consequence are unclear, altered proteolytic mechanisms within the cerebral vessel wall may be involved. We analyzed cerebral Aβ deposition in brains with AD and Dutch-type hereditary cerebral hemorrhage with amyloidosis (HCHWA-D) on the basis of two amyloid species of Aβ40 and Aβ42/43 using specific monoclonal antibodies. Compared to Aβ deposition in senile plaques, the molecular composition of Aβ was distinguishable, indicating that the Aβ40 species is the main component for vascular amyloid. Furthermore, we found Aβ42/43 immunoreactivity was also much increased in amyloid angiopathy of all cases with HCHWA-D. Taken together, amyloid angiopathy in HCHWA-D may share an Aβ42-driven deposition mechanism with plaque amyloid, resulting in enhanced Aβ40 deposition." @default.
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• W1978134798 date "2002-11-01" @default.
• W1978134798 modified "2023-09-24" @default.
• W1978134798 title "Enhanced Aβ₄₀Deposition Was Associated with Increased Aβ_42/43in Cerebral Vasculature with Dutch-Type Hereditary Cerebral Hemorrhage with Amyloidosis (HCHWA-D)" @default.
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• W1978134798 doi "https://doi.org/10.1111/j.1749-6632.2002.tb04810.x" @default.
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