Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978136585> ?p ?o ?g. }
- W1978136585 endingPage "1106" @default.
- W1978136585 startingPage "1097" @default.
- W1978136585 abstract "R82913 and R86183, two derivatives of tetrahydroimidazo[4,5,1-jk][1,4]-benzodiazepm-2(1H)-thione (TIBO), were found to potently and selectively inhibit the replication and cell killing effects of a panel of biologically diverse laboratory and clinical strains of HIV-1. The two compounds exhibited significant activity in all human cell lines tested, as well as in fresh human peripheral blood lymphocytes and macrophages. One of these two compounds (R82913) was found to significantly inhibit the replication of a murine retrovirus (Rauscher murine leukemia virus) in both UV-XC plaque formation and virus yield reduction assays. R86183, despite differing from R82913 only in the positioning of a single chlorine molecule, was not active against the murine retrovirus but was 10-fold more potent in inhibiting HIV-1 replication. Combination antiviral assays with other reverse transcriptase inhibitors, including AZT, ddC, and carbovir, yielded synergistic anti-HIV activity with both TIBO derivatives. Additive to slightly synergistic results were obtained in combinations with ddI and phosphonoformic acid whereas additive to antagonistic activity was detected in combination with dextran sulfate." @default.
- W1978136585 created "2016-06-24" @default.
- W1978136585 creator A5004481646 @default.
- W1978136585 creator A5005432621 @default.
- W1978136585 creator A5027623984 @default.
- W1978136585 creator A5046381609 @default.
- W1978136585 creator A5048844077 @default.
- W1978136585 creator A5080778766 @default.
- W1978136585 creator A5088134754 @default.
- W1978136585 date "1993-11-01" @default.
- W1978136585 modified "2023-10-16" @default.
- W1978136585 title "Differential Antiviral Activity of Two TIBO Derivatives Against the Human Immunodeficiency and Murine Leukemia Viruses Alone and in Combination with Other Anti-HIV Agents" @default.
- W1978136585 cites W1480548185 @default.
- W1978136585 cites W1489810714 @default.
- W1978136585 cites W1508703800 @default.
- W1978136585 cites W1968873679 @default.
- W1978136585 cites W1976683819 @default.
- W1978136585 cites W1977282539 @default.
- W1978136585 cites W1985881197 @default.
- W1978136585 cites W2007483635 @default.
- W1978136585 cites W2010546503 @default.
- W1978136585 cites W2011592728 @default.
- W1978136585 cites W2012995089 @default.
- W1978136585 cites W2018501180 @default.
- W1978136585 cites W2020331839 @default.
- W1978136585 cites W2028136402 @default.
- W1978136585 cites W2028143521 @default.
- W1978136585 cites W2029800977 @default.
- W1978136585 cites W2030484172 @default.
- W1978136585 cites W2040047403 @default.
- W1978136585 cites W2042695720 @default.
- W1978136585 cites W2055705838 @default.
- W1978136585 cites W2056686421 @default.
- W1978136585 cites W2067786897 @default.
- W1978136585 cites W2071313281 @default.
- W1978136585 cites W2072246943 @default.
- W1978136585 cites W2080291668 @default.
- W1978136585 cites W2086186867 @default.
- W1978136585 cites W2086462809 @default.
- W1978136585 cites W2093357483 @default.
- W1978136585 cites W2102973576 @default.
- W1978136585 cites W2104378500 @default.
- W1978136585 cites W2114162260 @default.
- W1978136585 cites W2114918609 @default.
- W1978136585 cites W2124217674 @default.
- W1978136585 cites W2143773220 @default.
- W1978136585 cites W2143788821 @default.
- W1978136585 cites W2165260654 @default.
- W1978136585 cites W2167716173 @default.
- W1978136585 cites W2434585129 @default.
- W1978136585 cites W4237110073 @default.
- W1978136585 cites W4256221661 @default.
- W1978136585 doi "https://doi.org/10.1089/aid.1993.9.1097" @default.
- W1978136585 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7508723" @default.
- W1978136585 hasPublicationYear "1993" @default.
- W1978136585 type Work @default.
- W1978136585 sameAs 1978136585 @default.
- W1978136585 citedByCount "17" @default.
- W1978136585 crossrefType "journal-article" @default.
- W1978136585 hasAuthorship W1978136585A5004481646 @default.
- W1978136585 hasAuthorship W1978136585A5005432621 @default.
- W1978136585 hasAuthorship W1978136585A5027623984 @default.
- W1978136585 hasAuthorship W1978136585A5046381609 @default.
- W1978136585 hasAuthorship W1978136585A5048844077 @default.
- W1978136585 hasAuthorship W1978136585A5080778766 @default.
- W1978136585 hasAuthorship W1978136585A5088134754 @default.
- W1978136585 hasConcept C104317684 @default.
- W1978136585 hasConcept C116073593 @default.
- W1978136585 hasConcept C140704245 @default.
- W1978136585 hasConcept C156719811 @default.
- W1978136585 hasConcept C159047783 @default.
- W1978136585 hasConcept C185592680 @default.
- W1978136585 hasConcept C202751555 @default.
- W1978136585 hasConcept C203014093 @default.
- W1978136585 hasConcept C2522874641 @default.
- W1978136585 hasConcept C2778431562 @default.
- W1978136585 hasConcept C2778461978 @default.
- W1978136585 hasConcept C2779562191 @default.
- W1978136585 hasConcept C54355233 @default.
- W1978136585 hasConcept C55493867 @default.
- W1978136585 hasConcept C67705224 @default.
- W1978136585 hasConcept C81885089 @default.
- W1978136585 hasConcept C86803240 @default.
- W1978136585 hasConceptScore W1978136585C104317684 @default.
- W1978136585 hasConceptScore W1978136585C116073593 @default.
- W1978136585 hasConceptScore W1978136585C140704245 @default.
- W1978136585 hasConceptScore W1978136585C156719811 @default.
- W1978136585 hasConceptScore W1978136585C159047783 @default.
- W1978136585 hasConceptScore W1978136585C185592680 @default.
- W1978136585 hasConceptScore W1978136585C202751555 @default.
- W1978136585 hasConceptScore W1978136585C203014093 @default.
- W1978136585 hasConceptScore W1978136585C2522874641 @default.
- W1978136585 hasConceptScore W1978136585C2778431562 @default.
- W1978136585 hasConceptScore W1978136585C2778461978 @default.
- W1978136585 hasConceptScore W1978136585C2779562191 @default.
- W1978136585 hasConceptScore W1978136585C54355233 @default.
- W1978136585 hasConceptScore W1978136585C55493867 @default.
- W1978136585 hasConceptScore W1978136585C67705224 @default.