Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978138384> ?p ?o ?g. }
- W1978138384 endingPage "2073" @default.
- W1978138384 startingPage "2061" @default.
- W1978138384 abstract "Huntington's disease (HD) is a devastating neurodegenerative disorder characterized by the progressive development of involuntary choreiform movements, cognitive impairment, neuropsychiatric symptoms, and premature death. These phenotypes reflect neuronal dysfunction and ultimately death in selected brain regions, the striatum and cerebral cortex being principal targets. The genetic mutation responsible for the HD phenotype is known, and its protein product, mutant huntingtin (mhtt), identified. HD is one of several triplet repeat diseases, in which abnormal expansions in trinucleotide repeat domains lead to elongated polyglutamine stretches in the affected gene's protein product. Mutant htt-mediated toxicity in the brain disrupts a number of vital cellular processes in the course of disease progression, including energy metabolism, gene transcription, clathrin-dependent endocytosis, intraneuronal trafficking, and postsynaptic signaling, but the crucial initiation mechanism induced by mhtt is still unclear. A large body of evidence, however, supports an early and critical involvement of defects in mitochondrial function and CNS energy metabolism in the disease trigger. Thus, downstream death-effector mechanisms, including excitotoxicity, apoptosis, and oxidative damage, have been implicated in the mechanism of selective neuronal damage in HD. Here we review the current evidence supporting a role for oxidative damage in the etiology of neuronal damage and degeneration in HD." @default.
- W1978138384 created "2016-06-24" @default.
- W1978138384 creator A5022054634 @default.
- W1978138384 creator A5057749582 @default.
- W1978138384 date "2006-11-01" @default.
- W1978138384 modified "2023-10-15" @default.
- W1978138384 title "Oxidative Damage in Huntington's Disease Pathogenesis" @default.
- W1978138384 cites W1494890404 @default.
- W1978138384 cites W1504816243 @default.
- W1978138384 cites W1515735942 @default.
- W1978138384 cites W1546480220 @default.
- W1978138384 cites W1565788467 @default.
- W1978138384 cites W1569800962 @default.
- W1978138384 cites W1578813045 @default.
- W1978138384 cites W1596467522 @default.
- W1978138384 cites W1606950487 @default.
- W1978138384 cites W1613986623 @default.
- W1978138384 cites W1647861543 @default.
- W1978138384 cites W1946022517 @default.
- W1978138384 cites W1958675123 @default.
- W1978138384 cites W1963552002 @default.
- W1978138384 cites W1964304043 @default.
- W1978138384 cites W1967145961 @default.
- W1978138384 cites W1970126151 @default.
- W1978138384 cites W1976547060 @default.
- W1978138384 cites W1977383752 @default.
- W1978138384 cites W1978190113 @default.
- W1978138384 cites W1986070505 @default.
- W1978138384 cites W1991174366 @default.
- W1978138384 cites W1991631628 @default.
- W1978138384 cites W1992037022 @default.
- W1978138384 cites W1994243055 @default.
- W1978138384 cites W1996592124 @default.
- W1978138384 cites W1999649376 @default.
- W1978138384 cites W2000484187 @default.
- W1978138384 cites W2002644780 @default.
- W1978138384 cites W2002742028 @default.
- W1978138384 cites W2002763309 @default.
- W1978138384 cites W2003061822 @default.
- W1978138384 cites W2004355943 @default.
- W1978138384 cites W2004767475 @default.
- W1978138384 cites W2004981183 @default.
- W1978138384 cites W2005608816 @default.
- W1978138384 cites W2005776786 @default.
- W1978138384 cites W2010145371 @default.
- W1978138384 cites W2014997175 @default.
- W1978138384 cites W2015236208 @default.
- W1978138384 cites W2015243552 @default.
- W1978138384 cites W2019527265 @default.
- W1978138384 cites W2019798350 @default.
- W1978138384 cites W2020918076 @default.
- W1978138384 cites W2022499907 @default.
- W1978138384 cites W2022851867 @default.
- W1978138384 cites W2026364404 @default.
- W1978138384 cites W2026460402 @default.
- W1978138384 cites W2028243150 @default.
- W1978138384 cites W2030258195 @default.
- W1978138384 cites W2031228038 @default.
- W1978138384 cites W2031574763 @default.
- W1978138384 cites W2032603387 @default.
- W1978138384 cites W2035752728 @default.
- W1978138384 cites W2035957913 @default.
- W1978138384 cites W2040535922 @default.
- W1978138384 cites W2042567578 @default.
- W1978138384 cites W2044695362 @default.
- W1978138384 cites W2044824361 @default.
- W1978138384 cites W2047298360 @default.
- W1978138384 cites W2048713258 @default.
- W1978138384 cites W2049387807 @default.
- W1978138384 cites W2050347556 @default.
- W1978138384 cites W2050878478 @default.
- W1978138384 cites W2051385624 @default.
- W1978138384 cites W2053919910 @default.
- W1978138384 cites W2054046372 @default.
- W1978138384 cites W2056119329 @default.
- W1978138384 cites W2057420304 @default.
- W1978138384 cites W2057810961 @default.
- W1978138384 cites W2060588252 @default.
- W1978138384 cites W2062359737 @default.
- W1978138384 cites W2062682951 @default.
- W1978138384 cites W2065979594 @default.
- W1978138384 cites W2067989457 @default.
- W1978138384 cites W2070381032 @default.
- W1978138384 cites W2071880115 @default.
- W1978138384 cites W2072396956 @default.
- W1978138384 cites W2074304614 @default.
- W1978138384 cites W2074410961 @default.
- W1978138384 cites W2076935230 @default.
- W1978138384 cites W2077298522 @default.
- W1978138384 cites W2077344726 @default.
- W1978138384 cites W2077846197 @default.
- W1978138384 cites W2079278002 @default.
- W1978138384 cites W2080305200 @default.
- W1978138384 cites W2082056883 @default.
- W1978138384 cites W2084639084 @default.
- W1978138384 cites W2085220812 @default.
- W1978138384 cites W2085266650 @default.
- W1978138384 cites W2086608701 @default.