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• W1978138923 endingPage "52" @default.
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• W1978138923 abstract "To evaluate the possible relationship between preeclampsia and polymorphisms in the main genes involved in folate-homocysteine metabolism.Case-control study: 43 patients with preeclampsia and 122 controls without pregnancy complications. Laboratory studies: tHcy and other amino acids, folate and vitamin B(12) and polymorphisms: 677C > T and 1298A > C (MTHFR); 699C > T, 844ins68 and 1080C > T (CBS); 2756A > G (MTR); and 66G > A, IVS1+766G > A and IVS1+754A > C (MTRR).Plasma tHcy and folate values were significantly higher (P = 0.004 and P = 0.019), while Met/tHcy ratios were lower (P < 0.001) in the patients compared with controls. No association was observed between polymorphisms tested and preeclampsia. In the control group, four such associations were found: the 1298A > C polymorphism (MTHFR) with the ratio Met/tHcy (P = 0.014); the 699C > T polymorphism (CBS) with the ratio tHcy/SigmaAA (P = 0.013); the 2756A > G polymorphism (MTR) with tHcy (P = 0.034); and the IVS1+766G > A polymorphism (MTRR) with hyperhomocysteinemia (P = 0.012).An association between the polymorphisms analysed and preeclampsia could not be demonstrated." @default.
• W1978138923 created "2016-06-24" @default.
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• W1978138923 date "2005-05-01" @default.
• W1978138923 modified "2023-10-16" @default.
• W1978138923 title "Polymorphisms of genes involved in homocysteine metabolism in preeclampsia and in uncomplicated pregnancies" @default.
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• W1978138923 doi "https://doi.org/10.1016/j.ejogrb.2004.08.008" @default.
• W1978138923 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15866085" @default.
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