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- W1978154436 abstract "To improve on the drug properties of GSK8062 1b, a series of heteroaryl bicyclic naphthalene replacements were prepared. The quinoline 1c was an equipotent FXR agonist with improved drug developability parameters relative to 1b. In addition, analog 1c lowered body weight gain and serum glucose in a DIO mouse model of diabetes." @default.
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- W1978154436 date "2011-02-01" @default.
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- W1978154436 title "Conformationally constrained farnesoid X receptor (FXR) agonists: Heteroaryl replacements of the naphthalene" @default.
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- W1978154436 doi "https://doi.org/10.1016/j.bmcl.2010.12.089" @default.
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