FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978159739> ?p ?o ?g. }

• W1978159739 endingPage "128" @default.
• W1978159739 startingPage "127" @default.
• W1978159739 abstract "Janssen et al in this journal published their paper “Measurement of pneumococcal polysaccharide vaccine responses for immunodeficiency diagnostics: combined IgG responses compared to serotype specific IgG responses”. It is important to note that the message of this study is the observation that measuring antibodies against a mixture of all 23 pneumococcal serotype polysaccharides by ELISA does not reliably identify patients with a deficient response to pneumococcal polysaccharides. This holds true for patients with CVID, Specific Antibody Deficiency (SAD) or any other immunodeficiency affecting antibody production. Therefore, this study confirms a finding that is well established and beyond question; the only way to properly assess the ability of producing IgG anti-pneumococcal antibodies is to measure antibodies to each serotype individually. This is particularly important in the diagnosis of SAD since this deficiency is defined as an abnormal response to pure pneumococcal polysacchrides, as in the 23-valent poneumococcal vaccine [1]. Now that most young patients are already vaccinated with a pneumococcal conjugate vaccine and may have developed antibodies to serotypes present in these vaccines, the global ELISA test would not be able to identify the lack of response to serotypes that are only in the 23-valent polysaccharide and not in the conjugate vaccines. The study by Janssen et al does lend further clarification about the value of the Luminex method for the diagnosis of SAD. The Luminex method is now used by most commercial laboratories in the USA because it offers significant logistic advantages over the well-standardized but more cumbersome WHO ELISA method. Luminex allows the simultaneous quantitation of multiple serotype-specific antibodies. Both the third generation WHO ELISA and Luminex based tests offered in the USA incorporate double absorption of samples with cell wall polysaccharide (CPS) and serotype 22F. The WHO ELISA test results have been shown to correlate closely with opsonophagocytosis (OPA) measurements [2, 3]. Although the Luminex method has been approved for the measurement of specific anti-pneumococcal serotype IgG antibodies, the correlation of this test with the standard ELISA test is poor and its use as s a diagnostic tool for SAD still needs further study. Recent studies designed to validate the Luminex assay for anti-pneumococcal IgG antibodies have shown different degrees of variability when compared to the ELISA method [4]. Results obtained in a recent comprehensive com-" @default.
• W1978159739 created "2016-06-24" @default.
• W1978159739 creator A5006834834 @default.
• W1978159739 creator A5068761013 @default.
• W1978159739 date "2013-12-17" @default.
• W1978159739 modified "2023-09-24" @default.
• W1978159739 title "Measurement of Pneumococcal Polysaccharide Antibodies" @default.
• W1978159739 cites W2033979699 @default.
• W1978159739 cites W2071303888 @default.
• W1978159739 cites W2113826000 @default.
• W1978159739 cites W2137140783 @default.
• W1978159739 cites W2150219782 @default.
• W1978159739 cites W2152563949 @default.
• W1978159739 cites W2156776857 @default.
• W1978159739 doi "https://doi.org/10.1007/s10875-013-9977-z" @default.
• W1978159739 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24337649" @default.
• W1978159739 hasPublicationYear "2013" @default.
• W1978159739 type Work @default.
• W1978159739 sameAs 1978159739 @default.
• W1978159739 citedByCount "11" @default.
• W1978159739 countsByYear W19781597392015 @default.
• W1978159739 countsByYear W19781597392016 @default.
• W1978159739 countsByYear W19781597392017 @default.
• W1978159739 countsByYear W19781597392018 @default.
• W1978159739 countsByYear W19781597392019 @default.
• W1978159739 countsByYear W19781597392021 @default.
• W1978159739 crossrefType "journal-article" @default.
• W1978159739 hasAuthorship W1978159739A5006834834 @default.
• W1978159739 hasAuthorship W1978159739A5068761013 @default.
• W1978159739 hasBestOaLocation W19781597391 @default.
• W1978159739 hasConcept C100817775 @default.
• W1978159739 hasConcept C159654299 @default.
• W1978159739 hasConcept C190139176 @default.
• W1978159739 hasConcept C203014093 @default.
• W1978159739 hasConcept C2776152631 @default.
• W1978159739 hasConcept C2781253189 @default.
• W1978159739 hasConcept C501593827 @default.
• W1978159739 hasConcept C55493867 @default.
• W1978159739 hasConcept C71924100 @default.
• W1978159739 hasConcept C86803240 @default.
• W1978159739 hasConcept C89423630 @default.
• W1978159739 hasConceptScore W1978159739C100817775 @default.
• W1978159739 hasConceptScore W1978159739C159654299 @default.
• W1978159739 hasConceptScore W1978159739C190139176 @default.
• W1978159739 hasConceptScore W1978159739C203014093 @default.
• W1978159739 hasConceptScore W1978159739C2776152631 @default.
• W1978159739 hasConceptScore W1978159739C2781253189 @default.
• W1978159739 hasConceptScore W1978159739C501593827 @default.
• W1978159739 hasConceptScore W1978159739C55493867 @default.
• W1978159739 hasConceptScore W1978159739C71924100 @default.
• W1978159739 hasConceptScore W1978159739C86803240 @default.
• W1978159739 hasConceptScore W1978159739C89423630 @default.
• W1978159739 hasIssue "2" @default.
• W1978159739 hasLocation W19781597391 @default.
• W1978159739 hasLocation W19781597392 @default.
• W1978159739 hasOpenAccess W1978159739 @default.
• W1978159739 hasPrimaryLocation W19781597391 @default.
• W1978159739 hasRelatedWork W2023363495 @default.
• W1978159739 hasRelatedWork W2048846203 @default.
• W1978159739 hasRelatedWork W2052638336 @default.
• W1978159739 hasRelatedWork W2064231049 @default.
• W1978159739 hasRelatedWork W2073623607 @default.
• W1978159739 hasRelatedWork W2140766375 @default.
• W1978159739 hasRelatedWork W2395374352 @default.
• W1978159739 hasRelatedWork W4221125579 @default.
• W1978159739 hasRelatedWork W4243618956 @default.
• W1978159739 hasRelatedWork W4292685773 @default.
• W1978159739 hasVolume "34" @default.
• W1978159739 isParatext "false" @default.
• W1978159739 isRetracted "false" @default.
• W1978159739 magId "1978159739" @default.
• W1978159739 workType "article" @default.