FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978162314> ?p ?o ?g. }

• W1978162314 endingPage "8408" @default.
• W1978162314 startingPage "8403" @default.
• W1978162314 abstract "The rotational barriers for cis/trans isomerization of different proline analogues have been investigated by dynamic 1H NMR spectroscopy. To this end the analogues (S)-azetidine-2-carboxylic acid (Aze), (S)-piperidine-2-carboxylic acid (Pip), (R)-thiazolidine-4-carboxylic acid (4-Thz), (4R)-2-methylthiazolidine-4-carboxylic acid (2Me4-Thz), (R)-thiazolidine-2-carboxylic acid (2-Thz), (S)-oxazolidine-4-carboxylic acid (4-Oxa), (4S,5R)-5-methyloxazolidine-4-carboxylic acid (5Me4-Oxa), and (2S,4R)-4-hydroxypyrrolidine-2-carboxylic acid (Hyp) and several N-alkylated amino acids were incorporated into the sequences Ala-Yaa-(4-)nitroanilide and Ala-Gly-Yaa-Phe-(4-)nitroanilide. NMR line-shape analyses of various cis and trans proton signals of these peptides were performed at different temperatures, and the rate constants of cis/trans isomerization were fitted to the Eyring equation. The rotational barriers of all cyclic proline analogues except hydroxyproline were found to be lower than that of proline by about 10 kJ/mol, whereas all noncyclic analogues and hydroxyproline showed rotational barriers similar to that observed for proline. In addition, the ability of cytosolic porcine kidney cyclophilin (Cyp18), a member of the peptidyl prolyl cis/trans isomerase family, to catalyze cis/trans isomerization of the peptide bond preceding the proline analogues was investigated. By line-shape analyses we proved efficient catalysis by Cyp18 for the analogues Aze, 4-Thz, and 2-Thz." @default.
• W1978162314 created "2016-06-24" @default.
• W1978162314 creator A5028974456 @default.
• W1978162314 creator A5059281644 @default.
• W1978162314 creator A5071376755 @default.
• W1978162314 date "1997-09-01" @default.
• W1978162314 modified "2023-10-16" @default.
• W1978162314 title "Rotational Barriers of<i>cis</i>/<i>trans</i>Isomerization of Proline Analogues and Their Catalysis by Cyclophilin" @default.
• W1978162314 cites W1518065087 @default.
• W1978162314 cites W1608807138 @default.
• W1978162314 cites W1973565326 @default.
• W1978162314 cites W1982359421 @default.
• W1978162314 cites W1987003587 @default.
• W1978162314 cites W1987069299 @default.
• W1978162314 cites W1988867706 @default.
• W1978162314 cites W1990916105 @default.
• W1978162314 cites W1993298978 @default.
• W1978162314 cites W1995713533 @default.
• W1978162314 cites W1999534434 @default.
• W1978162314 cites W2001101609 @default.
• W1978162314 cites W2014824579 @default.
• W1978162314 cites W2018937595 @default.
• W1978162314 cites W2032078761 @default.
• W1978162314 cites W2033186532 @default.
• W1978162314 cites W2034456773 @default.
• W1978162314 cites W2047981948 @default.
• W1978162314 cites W2050577453 @default.
• W1978162314 cites W2054009707 @default.
• W1978162314 cites W2061321625 @default.
• W1978162314 cites W2064700277 @default.
• W1978162314 cites W2066632833 @default.
• W1978162314 cites W2067435429 @default.
• W1978162314 cites W2080120713 @default.
• W1978162314 cites W2088572682 @default.
• W1978162314 cites W2152765932 @default.
• W1978162314 cites W2162061338 @default.
• W1978162314 cites W2176412414 @default.
• W1978162314 cites W2312974911 @default.
• W1978162314 cites W2949845322 @default.
• W1978162314 cites W2951371119 @default.
• W1978162314 cites W2952338976 @default.
• W1978162314 cites W4299953927 @default.
• W1978162314 doi "https://doi.org/10.1021/ja970606w" @default.
• W1978162314 hasPublicationYear "1997" @default.
• W1978162314 type Work @default.
• W1978162314 sameAs 1978162314 @default.
• W1978162314 citedByCount "112" @default.
• W1978162314 countsByYear W19781623142012 @default.
• W1978162314 countsByYear W19781623142013 @default.
• W1978162314 countsByYear W19781623142014 @default.
• W1978162314 countsByYear W19781623142015 @default.
• W1978162314 countsByYear W19781623142016 @default.
• W1978162314 countsByYear W19781623142017 @default.
• W1978162314 countsByYear W19781623142018 @default.
• W1978162314 countsByYear W19781623142019 @default.
• W1978162314 countsByYear W19781623142020 @default.
• W1978162314 countsByYear W19781623142021 @default.
• W1978162314 countsByYear W19781623142022 @default.
• W1978162314 countsByYear W19781623142023 @default.
• W1978162314 crossrefType "journal-article" @default.
• W1978162314 hasAuthorship W1978162314A5028974456 @default.
• W1978162314 hasAuthorship W1978162314A5059281644 @default.
• W1978162314 hasAuthorship W1978162314A5071376755 @default.
• W1978162314 hasConcept C109300003 @default.
• W1978162314 hasConcept C126661725 @default.
• W1978162314 hasConcept C161790260 @default.
• W1978162314 hasConcept C178790620 @default.
• W1978162314 hasConcept C185592680 @default.
• W1978162314 hasConcept C2779074116 @default.
• W1978162314 hasConcept C2779138802 @default.
• W1978162314 hasConcept C2779281246 @default.
• W1978162314 hasConcept C2779815552 @default.
• W1978162314 hasConcept C515207424 @default.
• W1978162314 hasConcept C55493867 @default.
• W1978162314 hasConcept C71240020 @default.
• W1978162314 hasConceptScore W1978162314C109300003 @default.
• W1978162314 hasConceptScore W1978162314C126661725 @default.
• W1978162314 hasConceptScore W1978162314C161790260 @default.
• W1978162314 hasConceptScore W1978162314C178790620 @default.
• W1978162314 hasConceptScore W1978162314C185592680 @default.
• W1978162314 hasConceptScore W1978162314C2779074116 @default.
• W1978162314 hasConceptScore W1978162314C2779138802 @default.
• W1978162314 hasConceptScore W1978162314C2779281246 @default.
• W1978162314 hasConceptScore W1978162314C2779815552 @default.
• W1978162314 hasConceptScore W1978162314C515207424 @default.
• W1978162314 hasConceptScore W1978162314C55493867 @default.
• W1978162314 hasConceptScore W1978162314C71240020 @default.
• W1978162314 hasIssue "36" @default.
• W1978162314 hasLocation W19781623141 @default.
• W1978162314 hasOpenAccess W1978162314 @default.
• W1978162314 hasPrimaryLocation W19781623141 @default.
• W1978162314 hasRelatedWork W1976479877 @default.
• W1978162314 hasRelatedWork W1985730748 @default.
• W1978162314 hasRelatedWork W2071434044 @default.
• W1978162314 hasRelatedWork W2078316230 @default.
• W1978162314 hasRelatedWork W2097754687 @default.
• W1978162314 hasRelatedWork W2111338933 @default.
• W1978162314 hasRelatedWork W2143361070 @default.

• next