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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978164637> ?p ?o ?g. }

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• W1978164637 abstract "A novel pyridothiophene inhibitor of PTP1B was discovered by rational screening of phosphotyrosine mimics at high micromolar concentrations. The potency of this lead compound has been improved significantly by medicinal chemistry guided by X-ray crystallography and molecular modeling. Excellent consistency has been observed between structure-activity relationships and structural information from PTP1B-inhibitor complexes." @default.
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• W1978164637 date "2006-04-01" @default.
• W1978164637 modified "2023-09-23" @default.
• W1978164637 title "Bicyclic and tricyclic thiophenes as protein tyrosine phosphatase 1B inhibitors" @default.
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• W1978164637 doi "https://doi.org/10.1016/j.bmc.2005.11.005" @default.
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