FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978165058> ?p ?o ?g. }

• W1978165058 endingPage "242" @default.
• W1978165058 startingPage "227" @default.
• W1978165058 abstract "Previous reports suggest that when rats are fed a carbohydrate-enriched diet they develop hyperinsulinemia associated with elevated blood pressure. The purpose of this study was to assess the vascular reactivity of fructose-treated rats to various pressor agents. Male Sprague Dawley rats (n = 24) were used for this study and were divided into two equal groups. One of the groups was fed normal rat chow and served as the control group, whereas the other group was fed a fructose-enriched diet for four weeks. Mean blood pressure was elevated in the fructose-treated rats at the end of the second week of fructose treatment and remained elevated for the remainder of the study. At the end of the second and fourth weeks of fructose treatment, six rats from each group were used to assess both in vivo and subsequently in vitro vascular reactivity to various pressor agents. The jugular vein and carotid artery were cannulated under anesthesia. Twenty four hours after recovery from surgery pressor responses to angiotensin II (AII) and phenylephrine (PE) were determined. Twenty four hours later rats were decapitated and the thoracic aorta was removed, cleaned of adhering fat and cut into ring segments for vascular reactivity studies. Tissues were suspended in muscle baths containing physiological saline solution and maintained at 37 degrees C. Dose-response curves were generated in the aorta in response to potassium chloride (KCl), AII and PE. At the end of the second week of fructose treatment pressor response to AII was significantly increased in the fructose-treated rats compared to the controls whereas there was no significant difference in pressor response to PE. There was no significant difference in pressor response to AII and PE between the two groups at the end of the fourth week of fructose treatment. In vitro contractile response of the aorta to AII and PE were significantly greater in the fructose-fed rats compared to the controls at the end of the second week of fructose treatment; however, there was no change in the EC50 between the two groups. At the end of the fourth week of fructose treatment, the contractile responses to AII and PE were similar in both groups, although the response to AII tended to be lower in the fructose-fed rat. There was no significant difference in the contractile response to potassium chloride or in acetylcholine-induced relaxation throughout the study. These results strongly suggest that hypertension in fructose-treated rats is associated with increased in vitro vascular reactivity to AII and PE in the early stages of hypertension." @default.
• W1978165058 created "2016-06-24" @default.
• W1978165058 creator A5047348046 @default.
• W1978165058 creator A5065721284 @default.
• W1978165058 date "1996-01-01" @default.
• W1978165058 modified "2023-10-18" @default.
• W1978165058 title "Vascular Reactivity to Phenylephrine and Angiotensin II in Hypertensive Rats Associated with Insulin Resistance" @default.
• W1978165058 cites W1967453642 @default.
• W1978165058 cites W1990440469 @default.
• W1978165058 cites W1991414208 @default.
• W1978165058 cites W1995852257 @default.
• W1978165058 cites W2013572211 @default.
• W1978165058 cites W2019523613 @default.
• W1978165058 cites W2037389124 @default.
• W1978165058 cites W2066439832 @default.
• W1978165058 cites W2072212642 @default.
• W1978165058 cites W2085404953 @default.
• W1978165058 cites W2085874419 @default.
• W1978165058 cites W2092013225 @default.
• W1978165058 cites W2112081198 @default.
• W1978165058 cites W2146186911 @default.
• W1978165058 cites W2152908150 @default.
• W1978165058 cites W2154554488 @default.
• W1978165058 cites W2167196393 @default.
• W1978165058 cites W2285935148 @default.
• W1978165058 cites W4213390502 @default.
• W1978165058 doi "https://doi.org/10.3109/10641969609081766" @default.
• W1978165058 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8869002" @default.
• W1978165058 hasPublicationYear "1996" @default.
• W1978165058 type Work @default.
• W1978165058 sameAs 1978165058 @default.
• W1978165058 citedByCount "46" @default.
• W1978165058 countsByYear W19781650582012 @default.
• W1978165058 countsByYear W19781650582014 @default.
• W1978165058 countsByYear W19781650582015 @default.
• W1978165058 countsByYear W19781650582016 @default.
• W1978165058 countsByYear W19781650582017 @default.
• W1978165058 countsByYear W19781650582018 @default.
• W1978165058 countsByYear W19781650582020 @default.
• W1978165058 countsByYear W19781650582022 @default.
• W1978165058 countsByYear W19781650582023 @default.
• W1978165058 crossrefType "journal-article" @default.
• W1978165058 hasAuthorship W1978165058A5047348046 @default.
• W1978165058 hasAuthorship W1978165058A5065721284 @default.
• W1978165058 hasConcept C126322002 @default.
• W1978165058 hasConcept C134018914 @default.
• W1978165058 hasConcept C185592680 @default.
• W1978165058 hasConcept C2776970464 @default.
• W1978165058 hasConcept C2777391703 @default.
• W1978165058 hasConcept C2777397205 @default.
• W1978165058 hasConcept C2777952589 @default.
• W1978165058 hasConcept C2779306644 @default.
• W1978165058 hasConcept C2779395532 @default.
• W1978165058 hasConcept C2779961880 @default.
• W1978165058 hasConcept C2779980429 @default.
• W1978165058 hasConcept C2780988686 @default.
• W1978165058 hasConcept C2908929049 @default.
• W1978165058 hasConcept C2992686903 @default.
• W1978165058 hasConcept C55493867 @default.
• W1978165058 hasConcept C71924100 @default.
• W1978165058 hasConcept C84393581 @default.
• W1978165058 hasConceptScore W1978165058C126322002 @default.
• W1978165058 hasConceptScore W1978165058C134018914 @default.
• W1978165058 hasConceptScore W1978165058C185592680 @default.
• W1978165058 hasConceptScore W1978165058C2776970464 @default.
• W1978165058 hasConceptScore W1978165058C2777391703 @default.
• W1978165058 hasConceptScore W1978165058C2777397205 @default.
• W1978165058 hasConceptScore W1978165058C2777952589 @default.
• W1978165058 hasConceptScore W1978165058C2779306644 @default.
• W1978165058 hasConceptScore W1978165058C2779395532 @default.
• W1978165058 hasConceptScore W1978165058C2779961880 @default.
• W1978165058 hasConceptScore W1978165058C2779980429 @default.
• W1978165058 hasConceptScore W1978165058C2780988686 @default.
• W1978165058 hasConceptScore W1978165058C2908929049 @default.
• W1978165058 hasConceptScore W1978165058C2992686903 @default.
• W1978165058 hasConceptScore W1978165058C55493867 @default.
• W1978165058 hasConceptScore W1978165058C71924100 @default.
• W1978165058 hasConceptScore W1978165058C84393581 @default.
• W1978165058 hasIssue "2" @default.
• W1978165058 hasLocation W19781650581 @default.
• W1978165058 hasLocation W19781650582 @default.
• W1978165058 hasOpenAccess W1978165058 @default.
• W1978165058 hasPrimaryLocation W19781650581 @default.
• W1978165058 hasRelatedWork W2012273189 @default.
• W1978165058 hasRelatedWork W2014369012 @default.
• W1978165058 hasRelatedWork W2032225465 @default.
• W1978165058 hasRelatedWork W2056849036 @default.
• W1978165058 hasRelatedWork W2094672900 @default.
• W1978165058 hasRelatedWork W2151350502 @default.
• W1978165058 hasRelatedWork W2159934098 @default.
• W1978165058 hasRelatedWork W2410789767 @default.
• W1978165058 hasRelatedWork W2418646588 @default.
• W1978165058 hasRelatedWork W2420781481 @default.
• W1978165058 hasVolume "18" @default.
• W1978165058 isParatext "false" @default.
• W1978165058 isRetracted "false" @default.
• W1978165058 magId "1978165058" @default.
• W1978165058 workType "article" @default.