FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978166265> ?p ?o ?g. }

• W1978166265 endingPage "239" @default.
• W1978166265 startingPage "233" @default.
• W1978166265 abstract "Purpose: To investigate the involvement of the extracellular signal-regulated kinase (ERK) signaling pathway after intravitrevous injection of glutamate in rat retina. Methods: Three groups of five Sprague-Dawley rats each were studied. Group I was a normal control group, intravitreal saline injections. In Group II, one eye received an intravitreal glutamate injection (375 nmol, dissolved in saline) while the contralateral eye served as control. In Group III, intravitreal PD98059 (100 μ mol, an inhibitor of ERK) injections were administered 1 hr before glutamate injections. Seven days after injections, phosphorylated (activated) ERK in retina was localized by immunohistochemistry and fluorescent double labeling of retinal cryosections. Specific ERK blockade was documented to assess the functional significance of activated ERK. TUNEL staining was performed to assess apoptotic cell death. Results: Expression of phosphorylated ERK in rat retina was observed in the inner nuclear layer, the outer nuclear layer, and the nerve fiber layer after 3 days intravitreous injection of glutamate, increasing significantly after 7 days. Double immunofluorescence labling demonstrated that the increased retinal immunostaining for phospho-ERK was predominantly localized to the retinal Müller cells after 7 days intravitreous injection of glutamate. Moreover, blocking activation of ERK significantly improved the number of TUNEL-positive cells in the eyes receiving intravitreal PD98059 injections compared with the eyes receiving glutamate injections. Conclusions: The ERK pathway is involved in signal transduction in the retina after excessive stimulation by glutamate, which may contribute to the antiapoptotic role in retinal ganglion cell death induced by glutamate." @default.
• W1978166265 created "2016-06-24" @default.
• W1978166265 creator A5000158009 @default.
• W1978166265 creator A5004667609 @default.
• W1978166265 creator A5016138149 @default.
• W1978166265 creator A5022154207 @default.
• W1978166265 creator A5022443428 @default.
• W1978166265 creator A5037509498 @default.
• W1978166265 date "2007-01-01" @default.
• W1978166265 modified "2023-10-17" @default.
• W1978166265 title "Role of Extracellular Signal-Regulated Kinase in Glutamate-Stimulated Apoptosis of Rat Retinal Ganglion Cells" @default.
• W1978166265 cites W1495983806 @default.
• W1978166265 cites W1550956633 @default.
• W1978166265 cites W1558237074 @default.
• W1978166265 cites W1581371910 @default.
• W1978166265 cites W1624526296 @default.
• W1978166265 cites W1972183007 @default.
• W1978166265 cites W1975951192 @default.
• W1978166265 cites W1977472414 @default.
• W1978166265 cites W1990668296 @default.
• W1978166265 cites W2012450998 @default.
• W1978166265 cites W2024602398 @default.
• W1978166265 cites W2025740683 @default.
• W1978166265 cites W2043033966 @default.
• W1978166265 cites W2044762414 @default.
• W1978166265 cites W2059017998 @default.
• W1978166265 cites W2059995799 @default.
• W1978166265 cites W2061447912 @default.
• W1978166265 cites W2065990347 @default.
• W1978166265 cites W2066963022 @default.
• W1978166265 cites W2071343567 @default.
• W1978166265 cites W2073034396 @default.
• W1978166265 cites W2075104267 @default.
• W1978166265 cites W2077411940 @default.
• W1978166265 cites W2084352924 @default.
• W1978166265 cites W2086305194 @default.
• W1978166265 cites W2088472722 @default.
• W1978166265 cites W2094155854 @default.
• W1978166265 cites W2117976722 @default.
• W1978166265 cites W2128493109 @default.
• W1978166265 cites W2142848667 @default.
• W1978166265 cites W2161997958 @default.
• W1978166265 cites W2162239484 @default.
• W1978166265 cites W2169355774 @default.
• W1978166265 cites W4211258630 @default.
• W1978166265 doi "https://doi.org/10.1080/02713680701226808" @default.
• W1978166265 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17453943" @default.
• W1978166265 hasPublicationYear "2007" @default.
• W1978166265 type Work @default.
• W1978166265 sameAs 1978166265 @default.
• W1978166265 citedByCount "19" @default.
• W1978166265 countsByYear W19781662652013 @default.
• W1978166265 countsByYear W19781662652014 @default.
• W1978166265 countsByYear W19781662652015 @default.
• W1978166265 countsByYear W19781662652016 @default.
• W1978166265 countsByYear W19781662652018 @default.
• W1978166265 countsByYear W19781662652020 @default.
• W1978166265 countsByYear W19781662652021 @default.
• W1978166265 crossrefType "journal-article" @default.
• W1978166265 hasAuthorship W1978166265A5000158009 @default.
• W1978166265 hasAuthorship W1978166265A5004667609 @default.
• W1978166265 hasAuthorship W1978166265A5016138149 @default.
• W1978166265 hasAuthorship W1978166265A5022154207 @default.
• W1978166265 hasAuthorship W1978166265A5022443428 @default.
• W1978166265 hasAuthorship W1978166265A5037509498 @default.
• W1978166265 hasConcept C134018914 @default.
• W1978166265 hasConcept C169760540 @default.
• W1978166265 hasConcept C170493617 @default.
• W1978166265 hasConcept C190283241 @default.
• W1978166265 hasConcept C196795494 @default.
• W1978166265 hasConcept C2777093970 @default.
• W1978166265 hasConcept C2777506830 @default.
• W1978166265 hasConcept C2777624874 @default.
• W1978166265 hasConcept C2778231335 @default.
• W1978166265 hasConcept C2780188069 @default.
• W1978166265 hasConcept C2780827179 @default.
• W1978166265 hasConcept C28406088 @default.
• W1978166265 hasConcept C55493867 @default.
• W1978166265 hasConcept C57074206 @default.
• W1978166265 hasConcept C61174792 @default.
• W1978166265 hasConcept C62478195 @default.
• W1978166265 hasConcept C86803240 @default.
• W1978166265 hasConcept C95444343 @default.
• W1978166265 hasConceptScore W1978166265C134018914 @default.
• W1978166265 hasConceptScore W1978166265C169760540 @default.
• W1978166265 hasConceptScore W1978166265C170493617 @default.
• W1978166265 hasConceptScore W1978166265C190283241 @default.
• W1978166265 hasConceptScore W1978166265C196795494 @default.
• W1978166265 hasConceptScore W1978166265C2777093970 @default.
• W1978166265 hasConceptScore W1978166265C2777506830 @default.
• W1978166265 hasConceptScore W1978166265C2777624874 @default.
• W1978166265 hasConceptScore W1978166265C2778231335 @default.
• W1978166265 hasConceptScore W1978166265C2780188069 @default.
• W1978166265 hasConceptScore W1978166265C2780827179 @default.
• W1978166265 hasConceptScore W1978166265C28406088 @default.
• W1978166265 hasConceptScore W1978166265C55493867 @default.
• W1978166265 hasConceptScore W1978166265C57074206 @default.
• W1978166265 hasConceptScore W1978166265C61174792 @default.

• next