Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978167274> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W1978167274 abstract "The NMDA receptor antagonist memantine is currently one of the “Gold Standard” therapeutics used in treating dementia. The efficacy of memantine has been demonstrated in numerous cognition models (Mobius et al., 2004; Martinez-Coria et al., 2010); however, a detailed analysis of the neurocircuitry involved in cognitive enhancement has not been conducted. In the current study, we have compared the effect of memantine in a rat model of recognition memory, thought to involve perirhinal cortex-hippocampal circuit i.e. novel object recognition (NOR), with quantitative 2-deoxyglucose (2-DG) autoradiography to understand the underlying neurocircuitry. The use of these techniques could provide translation methodologies to understand the mechanism of such agents. Memantine's effects (3, 10 and 30 mg/kg, s.c.) was examined using 2-DG autoradiography, in a total of 37 brain regions, in conscious rats. Memantine induced significant (P<0.05) dose-dependent increases in glucose utilization in limbic areas; e.g., posterior cingulate cortex (11-40%), hippocampus (1-58%), anterior thalamus (6-40%). Reductions in glucose usage were observed in the auditory cortex (0-23%), medial geniculate (1-15%) and inferior colliculus (20-22%). In the rat NOR, memantine (0.3, 1 and 3mg/kg i.p.; ptt 1 h) did not improve object recognition at the doses examined. Bioanalysis from the NOR study revealed free brain concentrations of 0.18uM, 0.50uM and 1.73uM (0.3, 1 and 3 mg/kg, i.p., respectively). Bioanalysis from the 2-DG study revealed free brain concentrations of 1.8uM and 13.9uM (3 and 30mg/kg, s.c. respectively). While memantine did not enhance object discrimination at the doses examined, we were unable to examine higher doses due to induction of stereotype behaviour in animals treated with >10 mg/kg. Memantine's effects on glucose utilization are consistent with its activity as an NMDA receptor antagonist, similar previous reports for MK-801 (Kurumaji et al. 1989). While a direct correlation cannot be made between the effects in the NOR and 2-DG in the current studies, activation of glutamatergic circuitry in the hippocampus/limbic system may be associated with the clinical pro-cognitive effects of this agent. However, the ability to use 2-DG as a truly translatable indicator for cognitive efficacy may suffer from sensitivity issues at least within the limited preclinical studies reported here." @default.
- W1978167274 created "2016-06-24" @default.
- W1978167274 creator A5006057213 @default.
- W1978167274 creator A5015867594 @default.
- W1978167274 creator A5028411455 @default.
- W1978167274 creator A5035113274 @default.
- W1978167274 creator A5056582539 @default.
- W1978167274 creator A5058940058 @default.
- W1978167274 creator A5072308975 @default.
- W1978167274 creator A5086201160 @default.
- W1978167274 date "2012-07-01" @default.
- W1978167274 modified "2023-09-27" @default.
- W1978167274 title "P1-298: Memantine: Assessment in novel object recognition and quantitative 2-deoxyglucose metabolism in rat" @default.
- W1978167274 doi "https://doi.org/10.1016/j.jalz.2012.05.2138" @default.
- W1978167274 hasPublicationYear "2012" @default.
- W1978167274 type Work @default.
- W1978167274 sameAs 1978167274 @default.
- W1978167274 citedByCount "0" @default.
- W1978167274 crossrefType "journal-article" @default.
- W1978167274 hasAuthorship W1978167274A5006057213 @default.
- W1978167274 hasAuthorship W1978167274A5015867594 @default.
- W1978167274 hasAuthorship W1978167274A5028411455 @default.
- W1978167274 hasAuthorship W1978167274A5035113274 @default.
- W1978167274 hasAuthorship W1978167274A5056582539 @default.
- W1978167274 hasAuthorship W1978167274A5058940058 @default.
- W1978167274 hasAuthorship W1978167274A5072308975 @default.
- W1978167274 hasAuthorship W1978167274A5086201160 @default.
- W1978167274 hasBestOaLocation W19781672741 @default.
- W1978167274 hasConcept C126322002 @default.
- W1978167274 hasConcept C148762608 @default.
- W1978167274 hasConcept C15744967 @default.
- W1978167274 hasConcept C169760540 @default.
- W1978167274 hasConcept C170493617 @default.
- W1978167274 hasConcept C185592680 @default.
- W1978167274 hasConcept C2775980177 @default.
- W1978167274 hasConcept C2779484449 @default.
- W1978167274 hasConcept C2780723820 @default.
- W1978167274 hasConcept C2780795376 @default.
- W1978167274 hasConcept C2781161787 @default.
- W1978167274 hasConcept C67018056 @default.
- W1978167274 hasConcept C71924100 @default.
- W1978167274 hasConcept C98274493 @default.
- W1978167274 hasConceptScore W1978167274C126322002 @default.
- W1978167274 hasConceptScore W1978167274C148762608 @default.
- W1978167274 hasConceptScore W1978167274C15744967 @default.
- W1978167274 hasConceptScore W1978167274C169760540 @default.
- W1978167274 hasConceptScore W1978167274C170493617 @default.
- W1978167274 hasConceptScore W1978167274C185592680 @default.
- W1978167274 hasConceptScore W1978167274C2775980177 @default.
- W1978167274 hasConceptScore W1978167274C2779484449 @default.
- W1978167274 hasConceptScore W1978167274C2780723820 @default.
- W1978167274 hasConceptScore W1978167274C2780795376 @default.
- W1978167274 hasConceptScore W1978167274C2781161787 @default.
- W1978167274 hasConceptScore W1978167274C67018056 @default.
- W1978167274 hasConceptScore W1978167274C71924100 @default.
- W1978167274 hasConceptScore W1978167274C98274493 @default.
- W1978167274 hasIssue "4S_Part_6" @default.
- W1978167274 hasLocation W19781672741 @default.
- W1978167274 hasOpenAccess W1978167274 @default.
- W1978167274 hasPrimaryLocation W19781672741 @default.
- W1978167274 hasRelatedWork W1524603704 @default.
- W1978167274 hasRelatedWork W1994870907 @default.
- W1978167274 hasRelatedWork W2009020263 @default.
- W1978167274 hasRelatedWork W2018213389 @default.
- W1978167274 hasRelatedWork W2029991684 @default.
- W1978167274 hasRelatedWork W2040587963 @default.
- W1978167274 hasRelatedWork W2067197474 @default.
- W1978167274 hasRelatedWork W2748952813 @default.
- W1978167274 hasRelatedWork W2751416439 @default.
- W1978167274 hasRelatedWork W2899084033 @default.
- W1978167274 hasVolume "8" @default.
- W1978167274 isParatext "false" @default.
- W1978167274 isRetracted "false" @default.
- W1978167274 magId "1978167274" @default.
- W1978167274 workType "article" @default.