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• W1978169039 abstract "The slope of in vivo CO2 titration curve (in vivo slope, d[HC0−3]p/dpHp, unit: slyke) changes with the time of exposure to altered Pco2 The effects of change in cardiac output during the titration with high Pco2 on the time course of change in the in vivo slope and on the value of the slope were investigated in anesthetized dogs. The titration was carried out by means of air and 90-min periods of CO2, breathing (12% C02–21% O2 in N2), the in vivo slope being determined at 5, 10, 30, 60 and 90 min of the CO-s breathing. In spontaneously breathing dogs there was a 60% increase in cardiac output during CO2 breathing and the in vivo slope reached an apparent steady state no later than 10 min. The arterial blood showed a greater slope (13 slyke) than the mixed venous blood (11 slyke) in these dogs. In dogs with controlled ventilation there was no increase in cardiac output during CO2 breathing and the apparent equilibration of the titration took 30 min. The in vivo slope was the same (8 slyke) in both of arterial and mixed venous blood. The lower slope value in the latter dogs was discussed in relation to a possible increase in the extracellular fluid volume during CO2 breathing." @default.
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• W1978169039 date "1974-08-01" @default.
• W1978169039 modified "2023-09-27" @default.
• W1978169039 title "Effect of cardiac output on the in vivo CO2 titration curve during acute breathing of CO2 in the dog" @default.
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• W1978169039 doi "https://doi.org/10.1016/0034-5687(74)90090-5" @default.
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