Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978169715> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W1978169715 endingPage "407" @default.
- W1978169715 startingPage "399" @default.
- W1978169715 abstract "This report describes a small, nonrandomized trial of cyclophosphamide in the treatment of patients with advanced thromboangiitis obliterans (TAO) with modest results. The rationale of the treatment was based on the immunopathogenesis of the disease, ie, autoimmune vasculitis of peripheral arteries. Twelve male patient volunteers with TAO were included for the trial. Diagnosis was based on the history of chronic smoking or tobacco chewing, clinical features of ischemia of peripheral vessels, radioarteriography showing arterial block, and characteristic histopathologic changes of affected arteries. Cyclophosphamide (400 mg) was given intra venously daily to the patients for 7 days followed by daily oral administration of 100 mg cyclophosphamide for another 7 weeks. Clinical conditions of the patients started to improve during the third week of the treatment and maximum benefit was noticed at the end of the treatment. There was significant decrease of intermittent claudication and twentyfold increase of claudication distance as well as relief of rest pain. Before starting treatment 6 patients had developed ulcers on their affected limbs; these healed completely in 2, partially healed in another 2, and showed no improvement in the remaining 2, who never stopped smoking. However, immunosuppressive therapy failed to show any improvement of arterial block, as evidenced by radioarteriography and any significant increase of skin temperature over the affected limbs. Nevertheless, histopathologic studies of biopsies taken from the diseased arteries after completion of therapy showed decreased influx of lymphocytes and plasma cells in the thrombi as well as in the arterial walls in comparison to the biopsies taken before the start of treatment. During the treatment the degree of immunosuppression was monitored by blood leukocyte and lymphocyte counts, which were kept between 4,000/mm 3 and above 3,000/mm 3 and not less than 500/mm 3 , respectively, indicating modest immunosuppression and no serious complications. All patients were followed up for 1 year. Only 2 patients, who resumed smoking, had relapse." @default.
- W1978169715 created "2016-06-24" @default.
- W1978169715 creator A5012398505 @default.
- W1978169715 creator A5021799104 @default.
- W1978169715 creator A5062280014 @default.
- W1978169715 date "2001-06-01" @default.
- W1978169715 modified "2023-10-07" @default.
- W1978169715 title "Treatment of Patients with Thromboangiitis Obliterans with Cyclophosphamide" @default.
- W1978169715 cites W1981429226 @default.
- W1978169715 cites W1995337523 @default.
- W1978169715 cites W2013132914 @default.
- W1978169715 cites W2056770551 @default.
- W1978169715 cites W2066193621 @default.
- W1978169715 cites W2069354548 @default.
- W1978169715 cites W2327085181 @default.
- W1978169715 doi "https://doi.org/10.1177/000331970105200605" @default.
- W1978169715 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11437030" @default.
- W1978169715 hasPublicationYear "2001" @default.
- W1978169715 type Work @default.
- W1978169715 sameAs 1978169715 @default.
- W1978169715 citedByCount "20" @default.
- W1978169715 countsByYear W19781697152012 @default.
- W1978169715 countsByYear W19781697152014 @default.
- W1978169715 countsByYear W19781697152016 @default.
- W1978169715 countsByYear W19781697152019 @default.
- W1978169715 countsByYear W19781697152020 @default.
- W1978169715 countsByYear W19781697152023 @default.
- W1978169715 crossrefType "journal-article" @default.
- W1978169715 hasAuthorship W1978169715A5012398505 @default.
- W1978169715 hasAuthorship W1978169715A5021799104 @default.
- W1978169715 hasAuthorship W1978169715A5062280014 @default.
- W1978169715 hasConcept C126322002 @default.
- W1978169715 hasConcept C141071460 @default.
- W1978169715 hasConcept C2776015282 @default.
- W1978169715 hasConcept C2776694085 @default.
- W1978169715 hasConcept C2776755627 @default.
- W1978169715 hasConcept C2777466421 @default.
- W1978169715 hasConcept C2778003345 @default.
- W1978169715 hasConcept C2778963770 @default.
- W1978169715 hasConcept C2779134260 @default.
- W1978169715 hasConcept C2779881954 @default.
- W1978169715 hasConcept C2781265703 @default.
- W1978169715 hasConcept C3018348675 @default.
- W1978169715 hasConcept C46762472 @default.
- W1978169715 hasConcept C71924100 @default.
- W1978169715 hasConceptScore W1978169715C126322002 @default.
- W1978169715 hasConceptScore W1978169715C141071460 @default.
- W1978169715 hasConceptScore W1978169715C2776015282 @default.
- W1978169715 hasConceptScore W1978169715C2776694085 @default.
- W1978169715 hasConceptScore W1978169715C2776755627 @default.
- W1978169715 hasConceptScore W1978169715C2777466421 @default.
- W1978169715 hasConceptScore W1978169715C2778003345 @default.
- W1978169715 hasConceptScore W1978169715C2778963770 @default.
- W1978169715 hasConceptScore W1978169715C2779134260 @default.
- W1978169715 hasConceptScore W1978169715C2779881954 @default.
- W1978169715 hasConceptScore W1978169715C2781265703 @default.
- W1978169715 hasConceptScore W1978169715C3018348675 @default.
- W1978169715 hasConceptScore W1978169715C46762472 @default.
- W1978169715 hasConceptScore W1978169715C71924100 @default.
- W1978169715 hasIssue "6" @default.
- W1978169715 hasLocation W19781697151 @default.
- W1978169715 hasLocation W19781697152 @default.
- W1978169715 hasOpenAccess W1978169715 @default.
- W1978169715 hasPrimaryLocation W19781697151 @default.
- W1978169715 hasRelatedWork W1695362599 @default.
- W1978169715 hasRelatedWork W1755130786 @default.
- W1978169715 hasRelatedWork W2065344458 @default.
- W1978169715 hasRelatedWork W2078591307 @default.
- W1978169715 hasRelatedWork W2082521078 @default.
- W1978169715 hasRelatedWork W2134693844 @default.
- W1978169715 hasRelatedWork W2147434290 @default.
- W1978169715 hasRelatedWork W2312232046 @default.
- W1978169715 hasRelatedWork W2409794065 @default.
- W1978169715 hasRelatedWork W4299701589 @default.
- W1978169715 hasVolume "52" @default.
- W1978169715 isParatext "false" @default.
- W1978169715 isRetracted "false" @default.
- W1978169715 magId "1978169715" @default.
- W1978169715 workType "article" @default.