FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978171107> ?p ?o ?g. }

• W1978171107 endingPage "184" @default.
• W1978171107 startingPage "177" @default.
• W1978171107 abstract "The Caf1 and LcrV sub-unit vaccine for plague has been shown to be highly protective against challenge with virulent Yersinia pestis in a mouse model. Production of large amounts of IgG1 in response to the vaccine correlates with protection against aerosol and parenteral infection. In this study the effect of genetic mutation in the immune system on protection was addressed. Stat 6(-/-) mice which are unable to utilise the type 2 cytokines IL-4 and IL-13 and so should have reduced IgG1 responses were utilised in order to determine whether an immune system biased towards the type 1 axis could mount an effective response to the vaccine. Conversely in the Stat 4(-/-) mouse model, IL-12 and interferon-gamma-mediated immune mechanisms are inactive and the immune response should be biased towards the type 2 axis. Serum antibody responses to vaccination in both the knockout strains and their wild type controls revealed little difference in levels of IgG and isotype profiles. Elispot analysis of cytokine production at the single cell level did however reveal a functional defect in the Stat 4(-/-) mice which had low levels of IFN-gamma producing cells. Following virulent challenge, the Stat 6(-/-) mice showed high levels of protection, while the Stat 4(-/-) mice were poorly protected, indicating a fundamental defect in their immune systems which could not be overcome even by the passive transfer of CD4(+) cells from immunised BALB/c donors. It appears therefore that type 1 immune mechanisms, activated following Stat 4 phosphorylation, are essential in protection against plague." @default.
• W1978171107 created "2016-06-24" @default.
• W1978171107 creator A5039486404 @default.
• W1978171107 creator A5047960778 @default.
• W1978171107 date "2004-10-01" @default.
• W1978171107 modified "2023-10-01" @default.
• W1978171107 title "Stat 4 but not Stat 6 mediated immune mechanisms are essential in protection against plague" @default.
• W1978171107 cites W1565566945 @default.
• W1978171107 cites W1571432809 @default.
• W1978171107 cites W1597981152 @default.
• W1978171107 cites W1781659395 @default.
• W1978171107 cites W1972922050 @default.
• W1978171107 cites W1975588465 @default.
• W1978171107 cites W1982093100 @default.
• W1978171107 cites W2002186586 @default.
• W1978171107 cites W2004162848 @default.
• W1978171107 cites W2005360556 @default.
• W1978171107 cites W2005971215 @default.
• W1978171107 cites W2007070422 @default.
• W1978171107 cites W2012628280 @default.
• W1978171107 cites W2019870550 @default.
• W1978171107 cites W2027699993 @default.
• W1978171107 cites W2031284514 @default.
• W1978171107 cites W2038271225 @default.
• W1978171107 cites W2041647537 @default.
• W1978171107 cites W2047153130 @default.
• W1978171107 cites W2060053956 @default.
• W1978171107 cites W2066584567 @default.
• W1978171107 cites W2095710623 @default.
• W1978171107 cites W2103195381 @default.
• W1978171107 cites W2104222407 @default.
• W1978171107 cites W2105005583 @default.
• W1978171107 cites W2106687873 @default.
• W1978171107 cites W2106811814 @default.
• W1978171107 cites W2108829772 @default.
• W1978171107 cites W2111952339 @default.
• W1978171107 cites W2123112413 @default.
• W1978171107 cites W2129280927 @default.
• W1978171107 cites W2131429686 @default.
• W1978171107 cites W2136057472 @default.
• W1978171107 cites W2139144899 @default.
• W1978171107 cites W2140707292 @default.
• W1978171107 cites W2144120552 @default.
• W1978171107 cites W2144230942 @default.
• W1978171107 cites W2144282160 @default.
• W1978171107 cites W2145912774 @default.
• W1978171107 cites W2156539371 @default.
• W1978171107 cites W2161458737 @default.
• W1978171107 cites W2169826855 @default.
• W1978171107 cites W2172466148 @default.
• W1978171107 cites W2334860433 @default.
• W1978171107 cites W4231704652 @default.
• W1978171107 cites W4244060517 @default.
• W1978171107 cites W4313374208 @default.
• W1978171107 doi "https://doi.org/10.1016/j.micpath.2004.06.009" @default.
• W1978171107 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15458778" @default.
• W1978171107 hasPublicationYear "2004" @default.
• W1978171107 type Work @default.
• W1978171107 sameAs 1978171107 @default.
• W1978171107 citedByCount "68" @default.
• W1978171107 countsByYear W19781711072012 @default.
• W1978171107 countsByYear W19781711072013 @default.
• W1978171107 countsByYear W19781711072014 @default.
• W1978171107 countsByYear W19781711072015 @default.
• W1978171107 countsByYear W19781711072016 @default.
• W1978171107 countsByYear W19781711072017 @default.
• W1978171107 countsByYear W19781711072018 @default.
• W1978171107 countsByYear W19781711072019 @default.
• W1978171107 countsByYear W19781711072020 @default.
• W1978171107 countsByYear W19781711072021 @default.
• W1978171107 countsByYear W19781711072023 @default.
• W1978171107 crossrefType "journal-article" @default.
• W1978171107 hasAuthorship W1978171107A5039486404 @default.
• W1978171107 hasAuthorship W1978171107A5047960778 @default.
• W1978171107 hasConcept C104317684 @default.
• W1978171107 hasConcept C159047783 @default.
• W1978171107 hasConcept C159654299 @default.
• W1978171107 hasConcept C187316574 @default.
• W1978171107 hasConcept C203014093 @default.
• W1978171107 hasConcept C2776090121 @default.
• W1978171107 hasConcept C2777789151 @default.
• W1978171107 hasConcept C2778277574 @default.
• W1978171107 hasConcept C2778690821 @default.
• W1978171107 hasConcept C2778910516 @default.
• W1978171107 hasConcept C2778923194 @default.
• W1978171107 hasConcept C2779053233 @default.
• W1978171107 hasConcept C547475151 @default.
• W1978171107 hasConcept C55493867 @default.
• W1978171107 hasConcept C60987743 @default.
• W1978171107 hasConcept C62478195 @default.
• W1978171107 hasConcept C86803240 @default.
• W1978171107 hasConcept C8891405 @default.
• W1978171107 hasConcept C89423630 @default.
• W1978171107 hasConcept C95444343 @default.
• W1978171107 hasConceptScore W1978171107C104317684 @default.
• W1978171107 hasConceptScore W1978171107C159047783 @default.
• W1978171107 hasConceptScore W1978171107C159654299 @default.
• W1978171107 hasConceptScore W1978171107C187316574 @default.

• next