Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978171141> ?p ?o ?g. }
- W1978171141 endingPage "187" @default.
- W1978171141 startingPage "177" @default.
- W1978171141 abstract "Fibronectin is an extracellular matrix glycoprotein that plays a role in a number of physiological processes involving cell adhesion and migration. The modules of the fibronectin monomer are organized into proteolytically resistant domains that in isolation retain their affinity for various ligands. The tertiary structure of the glycosylated second type 2 module (2F2) from the gelatin-binding domain of fibronectin was determined by two-dimensional nuclear magnetic resonance spectroscopy and simulated annealing. The structure is well defined with an overall fold typical of F2 modules, showing two double-stranded antiparallel β-sheets and a partially solvent-exposed hydrophobic cluster. An N-terminal β-sheet, that was not present in previously determined F2 module structures, may be important for defining the relative orientation of adjacent F2 modules in fibronectin. This is the first three-dimensional structure of a glycosylated module of fibronectin, and provides insight into the possible role of the glycosylation in protein stability, protease resistance and modulation of collagen binding. Based on the structures of the isolated modules, models for the 1F22F2 pair were generated by randomly changing the orientation of the linker peptide between the modules. The models suggest that the two putative collagen binding sites in the pair form discrete binding sites, rather than combining to form a single binding site." @default.
- W1978171141 created "2016-06-24" @default.
- W1978171141 creator A5029139656 @default.
- W1978171141 creator A5062219892 @default.
- W1978171141 creator A5065393453 @default.
- W1978171141 creator A5073227677 @default.
- W1978171141 date "1998-02-01" @default.
- W1978171141 modified "2023-09-23" @default.
- W1978171141 title "Solution structure of the glycosylated second type 2 module of fibronectin" @default.
- W1978171141 cites W146078149 @default.
- W1978171141 cites W1493973784 @default.
- W1978171141 cites W1505980680 @default.
- W1978171141 cites W1512610726 @default.
- W1978171141 cites W1521214092 @default.
- W1978171141 cites W1523753692 @default.
- W1978171141 cites W1539737337 @default.
- W1978171141 cites W1551214592 @default.
- W1978171141 cites W1551764266 @default.
- W1978171141 cites W1560533935 @default.
- W1978171141 cites W1565629313 @default.
- W1978171141 cites W1785416487 @default.
- W1978171141 cites W1806896498 @default.
- W1978171141 cites W1969270088 @default.
- W1978171141 cites W1972211482 @default.
- W1978171141 cites W1986191025 @default.
- W1978171141 cites W1991431332 @default.
- W1978171141 cites W1993844842 @default.
- W1978171141 cites W1994654291 @default.
- W1978171141 cites W2011009086 @default.
- W1978171141 cites W2015064119 @default.
- W1978171141 cites W2016098772 @default.
- W1978171141 cites W2016597855 @default.
- W1978171141 cites W2022524633 @default.
- W1978171141 cites W2023129928 @default.
- W1978171141 cites W2028231353 @default.
- W1978171141 cites W2031952552 @default.
- W1978171141 cites W2035266068 @default.
- W1978171141 cites W2038770548 @default.
- W1978171141 cites W2041654633 @default.
- W1978171141 cites W2043382734 @default.
- W1978171141 cites W2044082153 @default.
- W1978171141 cites W2044417561 @default.
- W1978171141 cites W2044618920 @default.
- W1978171141 cites W2045446885 @default.
- W1978171141 cites W2053863608 @default.
- W1978171141 cites W2053919896 @default.
- W1978171141 cites W2063860401 @default.
- W1978171141 cites W2065326377 @default.
- W1978171141 cites W2065374074 @default.
- W1978171141 cites W2071253344 @default.
- W1978171141 cites W2075114519 @default.
- W1978171141 cites W2078057379 @default.
- W1978171141 cites W2078248419 @default.
- W1978171141 cites W2088848851 @default.
- W1978171141 cites W2098164044 @default.
- W1978171141 cites W2118969564 @default.
- W1978171141 cites W2162166182 @default.
- W1978171141 cites W2166739931 @default.
- W1978171141 cites W294768117 @default.
- W1978171141 cites W2951614986 @default.
- W1978171141 cites W4293253343 @default.
- W1978171141 cites W96913086 @default.
- W1978171141 cites W1986061992 @default.
- W1978171141 doi "https://doi.org/10.1006/jmbi.1997.1528" @default.
- W1978171141 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9514732" @default.
- W1978171141 hasPublicationYear "1998" @default.
- W1978171141 type Work @default.
- W1978171141 sameAs 1978171141 @default.
- W1978171141 citedByCount "50" @default.
- W1978171141 countsByYear W19781711412013 @default.
- W1978171141 countsByYear W19781711412014 @default.
- W1978171141 countsByYear W19781711412015 @default.
- W1978171141 countsByYear W19781711412016 @default.
- W1978171141 countsByYear W19781711412019 @default.
- W1978171141 countsByYear W19781711412020 @default.
- W1978171141 countsByYear W19781711412021 @default.
- W1978171141 crossrefType "journal-article" @default.
- W1978171141 hasAuthorship W1978171141A5029139656 @default.
- W1978171141 hasAuthorship W1978171141A5062219892 @default.
- W1978171141 hasAuthorship W1978171141A5065393453 @default.
- W1978171141 hasAuthorship W1978171141A5073227677 @default.
- W1978171141 hasConcept C107824862 @default.
- W1978171141 hasConcept C108625454 @default.
- W1978171141 hasConcept C111919701 @default.
- W1978171141 hasConcept C115260700 @default.
- W1978171141 hasConcept C121332964 @default.
- W1978171141 hasConcept C12554922 @default.
- W1978171141 hasConcept C142089489 @default.
- W1978171141 hasConcept C185592680 @default.
- W1978171141 hasConcept C189165786 @default.
- W1978171141 hasConcept C2777313579 @default.
- W1978171141 hasConcept C2780557392 @default.
- W1978171141 hasConcept C41008148 @default.
- W1978171141 hasConcept C47701112 @default.
- W1978171141 hasConcept C55493867 @default.
- W1978171141 hasConcept C62520636 @default.
- W1978171141 hasConcept C75599170 @default.
- W1978171141 hasConcept C8010536 @default.