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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978171909> ?p ?o ?g. }

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• W1978171909 abstract "A highly convergent synthesis of c-Met kinase inhibitor 1 has been demonstrated on a multikilogram scale using three key fragments: dihalotricyclic core 2, chiral sulfamide side chain 3, and pyrazole boronic ester 4. The chirality in sulfamide side chain 3 was installed using the cheap and readily available starting material (S)-epichlorohydrin. A total of 2.71 kg of 1 were isolated in seven steps (the longest linear sequence)." @default.
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• W1978171909 date "2010-06-02" @default.
• W1978171909 modified "2023-10-09" @default.
• W1978171909 title "Process Development and Large-Scale Synthesis of a c-Met Kinase Inhibitor" @default.
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• W1978171909 doi "https://doi.org/10.1021/op100101q" @default.
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