FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978174983> ?p ?o ?g. }

• W1978174983 endingPage "e87974" @default.
• W1978174983 startingPage "e87974" @default.
• W1978174983 abstract "Background Different parameters have been determined for prediction of treatment outcome in hepatitis c virus genotype 1 infected patients undergoing pegylated interferon, ribavirin combination therapy. Results on the importance of vitamin D levels are conflicting. In the present study, a comprehensive analysis of vitamin D levels before and during therapy together with single nucleotide polymorphisms involved in vitamin D metabolism in the context of other known treatment predictors has been performed. Methods In a well characterized prospective cohort of 398 genotype 1 infected patients treated with pegylated interferon-α and ribavirin for 24–72 weeks (INDIV-2 study) 25-OH-vitamin D levels and different single nucleotide polymorphisms were analyzed together with known biochemical parameters for a correlation with virologic treatment outcome. Results Fluctuations of more than 5 (10) ng/ml in 25-OH-vitamin D-levels have been observed in 66 (39) % of patients during the course of antiviral therapy and neither pretreatment nor under treatment 25-OH-vitamin D-levels were associated with treatment outcome. The DHCR7-TT-polymorphism within the 7-dehydrocholesterol-reductase showed a significant association (P = 0.031) to sustained viral response in univariate analysis. Among numerous further parameters analyzed we found that age (OR = 1.028, CI = 1.002–1.056, P = 0.035), cholesterol (OR = 0.983, CI = 0.975–0.991, P<0.001), ferritin (OR = 1.002, CI = 1.000–1.004, P = 0.033), gGT (OR = 1.467, CI = 1.073–2.006, P = 0.016) and IL28B-genotype (OR = 2.442, CI = 1.271–4.695, P = 0.007) constituted the strongest predictors of treatment response. Conclusions While 25-OH-vitamin D-levels levels show considerable variations during the long-lasting course of antiviral therapy they do not show any significant association to treatment outcome in genotype 1 infected patients." @default.
• W1978174983 created "2016-06-24" @default.
• W1978174983 creator A5001767163 @default.
• W1978174983 creator A5002417517 @default.
• W1978174983 creator A5005730211 @default.
• W1978174983 creator A5010474616 @default.
• W1978174983 creator A5025448215 @default.
• W1978174983 creator A5037590928 @default.
• W1978174983 creator A5040585455 @default.
• W1978174983 creator A5043408739 @default.
• W1978174983 creator A5045504446 @default.
• W1978174983 creator A5053937821 @default.
• W1978174983 creator A5054826514 @default.
• W1978174983 creator A5058986301 @default.
• W1978174983 creator A5059727947 @default.
• W1978174983 creator A5065708581 @default.
• W1978174983 creator A5070817587 @default.
• W1978174983 creator A5073576080 @default.
• W1978174983 creator A5079850830 @default.
• W1978174983 creator A5082309779 @default.
• W1978174983 date "2014-02-07" @default.
• W1978174983 modified "2023-09-29" @default.
• W1978174983 title "Vitamin D Levels Vary during Antiviral Treatment but Are Unable to Predict Treatment Outcome in HCV Genotype 1 Infected Patients" @default.
• W1978174983 cites W1515369159 @default.
• W1978174983 cites W1980339686 @default.
• W1978174983 cites W1980850694 @default.
• W1978174983 cites W1994894622 @default.
• W1978174983 cites W2011725731 @default.
• W1978174983 cites W2014361783 @default.
• W1978174983 cites W2023400145 @default.
• W1978174983 cites W2028350152 @default.
• W1978174983 cites W2041968388 @default.
• W1978174983 cites W2044276375 @default.
• W1978174983 cites W2052572105 @default.
• W1978174983 cites W2063285149 @default.
• W1978174983 cites W2064837363 @default.
• W1978174983 cites W2077159378 @default.
• W1978174983 cites W2079105341 @default.
• W1978174983 cites W2083924402 @default.
• W1978174983 cites W2093977114 @default.
• W1978174983 cites W2099554024 @default.
• W1978174983 cites W2102792873 @default.
• W1978174983 cites W2107119529 @default.
• W1978174983 cites W2117297406 @default.
• W1978174983 cites W2131037984 @default.
• W1978174983 cites W2131124463 @default.
• W1978174983 cites W2139840047 @default.
• W1978174983 cites W2147244844 @default.
• W1978174983 cites W2153059487 @default.
• W1978174983 cites W2155640444 @default.
• W1978174983 cites W2162258804 @default.
• W1978174983 cites W4246717824 @default.
• W1978174983 doi "https://doi.org/10.1371/journal.pone.0087974" @default.
• W1978174983 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3917831" @default.
• W1978174983 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24516573" @default.
• W1978174983 hasPublicationYear "2014" @default.
• W1978174983 type Work @default.
• W1978174983 sameAs 1978174983 @default.
• W1978174983 citedByCount "18" @default.
• W1978174983 countsByYear W19781749832014 @default.
• W1978174983 countsByYear W19781749832015 @default.
• W1978174983 countsByYear W19781749832016 @default.
• W1978174983 countsByYear W19781749832017 @default.
• W1978174983 countsByYear W19781749832018 @default.
• W1978174983 countsByYear W19781749832019 @default.
• W1978174983 countsByYear W19781749832020 @default.
• W1978174983 countsByYear W19781749832023 @default.
• W1978174983 crossrefType "journal-article" @default.
• W1978174983 hasAuthorship W1978174983A5001767163 @default.
• W1978174983 hasAuthorship W1978174983A5002417517 @default.
• W1978174983 hasAuthorship W1978174983A5005730211 @default.
• W1978174983 hasAuthorship W1978174983A5010474616 @default.
• W1978174983 hasAuthorship W1978174983A5025448215 @default.
• W1978174983 hasAuthorship W1978174983A5037590928 @default.
• W1978174983 hasAuthorship W1978174983A5040585455 @default.
• W1978174983 hasAuthorship W1978174983A5043408739 @default.
• W1978174983 hasAuthorship W1978174983A5045504446 @default.
• W1978174983 hasAuthorship W1978174983A5053937821 @default.
• W1978174983 hasAuthorship W1978174983A5054826514 @default.
• W1978174983 hasAuthorship W1978174983A5058986301 @default.
• W1978174983 hasAuthorship W1978174983A5059727947 @default.
• W1978174983 hasAuthorship W1978174983A5065708581 @default.
• W1978174983 hasAuthorship W1978174983A5070817587 @default.
• W1978174983 hasAuthorship W1978174983A5073576080 @default.
• W1978174983 hasAuthorship W1978174983A5079850830 @default.
• W1978174983 hasAuthorship W1978174983A5082309779 @default.
• W1978174983 hasBestOaLocation W19781749831 @default.
• W1978174983 hasConcept C104317684 @default.
• W1978174983 hasConcept C124490489 @default.
• W1978174983 hasConcept C126322002 @default.
• W1978174983 hasConcept C135763542 @default.
• W1978174983 hasConcept C142462285 @default.
• W1978174983 hasConcept C144301174 @default.
• W1978174983 hasConcept C151730666 @default.
• W1978174983 hasConcept C188816634 @default.
• W1978174983 hasConcept C203014093 @default.
• W1978174983 hasConcept C2522874641 @default.
• W1978174983 hasConcept C2776408679 @default.

• next