FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978185825> ?p ?o ?g. }

• W1978185825 endingPage "544" @default.
• W1978185825 startingPage "535" @default.
• W1978185825 abstract "For years activated natural killer (A-NK) cells have been explored with respect to their efficacy in anticancer therapy, but, except for some anectdotal reports, no clear clinical benefit has been shown. However, as the understanding about the interactions of NK cells and tumor cells advances, the use of A-NK cells might be revisited with more sophisticated approaches that pay tribute to mechanisms which allow tumor cells to escape immune surveillance. Here the highly cytotoxic NK cell line NK-92 seems to be an attractive alternative for use in adoptive immunotherapy, because it was shown to exhibit substantial antitumor activity against a wide range of malignancies in vitro as well as in xenografted SCID mice. NK-92 cells are characterized by an almost complete lack of killer cell immunglobulin-like receptors (KIRs) yet conserved ability to perforin and granzyme B-mediated cytolytic activity, which make them unique among the few established NK and T cell-like cell lines. NK-92 is the only natural killer cell line that has entered clinical trials. Here we discuss the current status of development of this cell line for adoptive immunotherapy (AIT) of malignancies and review our first clinical experience in patients with advanced cancer who have received repeated transfusions of irradiated NK-92 in a phase I/II trial. Also we discuss issues that address safety aspects of immunotherapy with clonal cell lines and describe further manipulations, which hold the potential of significantly improving the clinical outcome of AIT with NK-92." @default.
• W1978185825 created "2016-06-24" @default.
• W1978185825 creator A5016512953 @default.
• W1978185825 creator A5023566246 @default.
• W1978185825 creator A5033962209 @default.
• W1978185825 creator A5050893255 @default.
• W1978185825 creator A5088797832 @default.
• W1978185825 date "2001-08-01" @default.
• W1978185825 modified "2023-10-17" @default.
• W1978185825 title "Cellular Immunotherapy of Malignancies Using the Clonal Natural Killer Cell Line NK-92" @default.
• W1978185825 cites W170775584 @default.
• W1978185825 cites W1828347693 @default.
• W1978185825 cites W1970684135 @default.
• W1978185825 cites W1971376737 @default.
• W1978185825 cites W1976805459 @default.
• W1978185825 cites W1979126033 @default.
• W1978185825 cites W1985737513 @default.
• W1978185825 cites W1995792910 @default.
• W1978185825 cites W1999664609 @default.
• W1978185825 cites W2002584683 @default.
• W1978185825 cites W2002807798 @default.
• W1978185825 cites W2003398703 @default.
• W1978185825 cites W2018238733 @default.
• W1978185825 cites W2019441155 @default.
• W1978185825 cites W2029374116 @default.
• W1978185825 cites W2039609199 @default.
• W1978185825 cites W2040044146 @default.
• W1978185825 cites W2043830286 @default.
• W1978185825 cites W2055662879 @default.
• W1978185825 cites W2062799513 @default.
• W1978185825 cites W2068602959 @default.
• W1978185825 cites W2070762522 @default.
• W1978185825 cites W2085479979 @default.
• W1978185825 cites W2085781143 @default.
• W1978185825 cites W2112041130 @default.
• W1978185825 cites W2113715693 @default.
• W1978185825 cites W2116483935 @default.
• W1978185825 cites W2130649175 @default.
• W1978185825 cites W2135358991 @default.
• W1978185825 cites W2143005230 @default.
• W1978185825 cites W2143381422 @default.
• W1978185825 cites W2175497556 @default.
• W1978185825 cites W2317109657 @default.
• W1978185825 cites W2420284819 @default.
• W1978185825 cites W335139118 @default.
• W1978185825 doi "https://doi.org/10.1089/15258160152509145" @default.
• W1978185825 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11522236" @default.
• W1978185825 hasPublicationYear "2001" @default.
• W1978185825 type Work @default.
• W1978185825 sameAs 1978185825 @default.
• W1978185825 citedByCount "224" @default.
• W1978185825 countsByYear W19781858252012 @default.
• W1978185825 countsByYear W19781858252013 @default.
• W1978185825 countsByYear W19781858252014 @default.
• W1978185825 countsByYear W19781858252015 @default.
• W1978185825 countsByYear W19781858252016 @default.
• W1978185825 countsByYear W19781858252017 @default.
• W1978185825 countsByYear W19781858252018 @default.
• W1978185825 countsByYear W19781858252019 @default.
• W1978185825 countsByYear W19781858252020 @default.
• W1978185825 countsByYear W19781858252021 @default.
• W1978185825 countsByYear W19781858252022 @default.
• W1978185825 countsByYear W19781858252023 @default.
• W1978185825 crossrefType "journal-article" @default.
• W1978185825 hasAuthorship W1978185825A5016512953 @default.
• W1978185825 hasAuthorship W1978185825A5023566246 @default.
• W1978185825 hasAuthorship W1978185825A5033962209 @default.
• W1978185825 hasAuthorship W1978185825A5050893255 @default.
• W1978185825 hasAuthorship W1978185825A5088797832 @default.
• W1978185825 hasConcept C10882517 @default.
• W1978185825 hasConcept C129374314 @default.
• W1978185825 hasConcept C1491633281 @default.
• W1978185825 hasConcept C154317977 @default.
• W1978185825 hasConcept C167672396 @default.
• W1978185825 hasConcept C183193105 @default.
• W1978185825 hasConcept C202751555 @default.
• W1978185825 hasConcept C203014093 @default.
• W1978185825 hasConcept C206191192 @default.
• W1978185825 hasConcept C2776062744 @default.
• W1978185825 hasConcept C2776090121 @default.
• W1978185825 hasConcept C2777701055 @default.
• W1978185825 hasConcept C2778102761 @default.
• W1978185825 hasConcept C2780380082 @default.
• W1978185825 hasConcept C2780674031 @default.
• W1978185825 hasConcept C28651165 @default.
• W1978185825 hasConcept C502942594 @default.
• W1978185825 hasConcept C54355233 @default.
• W1978185825 hasConcept C55493867 @default.
• W1978185825 hasConcept C73588182 @default.
• W1978185825 hasConcept C86803240 @default.
• W1978185825 hasConcept C8891405 @default.
• W1978185825 hasConcept C90375314 @default.
• W1978185825 hasConceptScore W1978185825C10882517 @default.
• W1978185825 hasConceptScore W1978185825C129374314 @default.
• W1978185825 hasConceptScore W1978185825C1491633281 @default.
• W1978185825 hasConceptScore W1978185825C154317977 @default.
• W1978185825 hasConceptScore W1978185825C167672396 @default.
• W1978185825 hasConceptScore W1978185825C183193105 @default.

• next