FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978187092> ?p ?o ?g. }

• W1978187092 endingPage "e25747" @default.
• W1978187092 startingPage "e25747" @default.
• W1978187092 abstract "GLUT4 is a predominant insulin regulated glucose transporter expressed in major glucose disposal tissues such as adipocytes and muscles. Under the unstimulated state, GLUT4 resides within intracellular vesicles. Various stimuli such as insulin translocate this protein to the plasma membrane for glucose transport. In the absence of a crystal structure for GLUT4, very little is known about the mechanism of glucose transport by this protein. Earlier we proposed a homology model for GLUT4 and performed a conventional molecular dynamics study revealing the conformational rearrangements during glucose and ATP binding. However, this study could not explain the transport of glucose through the permeation tunnel.To elucidate the molecular mechanism of glucose transport and its energetic, a steered molecular dynamics study (SMD) was used. Glucose was pulled from the extracellular end of GLUT4 to the cytoplasm along the pathway using constant velocity pulling method. We identified several key residues within the tunnel that interact directly with either the backbone ring or the hydroxyl groups of glucose. A rotation of glucose molecule was seen near the sugar binding site facilitating the sugar recognition process at the QLS binding site.This study proposes a possible glucose transport pathway and aids the identification of several residues that make direct interactions with glucose during glucose transport. Mutational studies are required to further validate the observation made in this study." @default.
• W1978187092 created "2016-06-24" @default.
• W1978187092 creator A5013236796 @default.
• W1978187092 creator A5065578013 @default.
• W1978187092 creator A5066235342 @default.
• W1978187092 creator A5086388372 @default.
• W1978187092 date "2011-10-12" @default.
• W1978187092 modified "2023-10-01" @default.
• W1978187092 title "Elucidation of the Glucose Transport Pathway in Glucose Transporter 4 via Steered Molecular Dynamics Simulations" @default.
• W1978187092 cites W114297905 @default.
• W1978187092 cites W1483341493 @default.
• W1978187092 cites W1501783721 @default.
• W1978187092 cites W1506378995 @default.
• W1978187092 cites W1522565876 @default.
• W1978187092 cites W1561268569 @default.
• W1978187092 cites W1966067767 @default.
• W1978187092 cites W1968200351 @default.
• W1978187092 cites W1969155894 @default.
• W1978187092 cites W1985588649 @default.
• W1978187092 cites W1993777599 @default.
• W1978187092 cites W1994965139 @default.
• W1978187092 cites W1995272366 @default.
• W1978187092 cites W2002060713 @default.
• W1978187092 cites W2009181620 @default.
• W1978187092 cites W2011544982 @default.
• W1978187092 cites W2014712607 @default.
• W1978187092 cites W2015649064 @default.
• W1978187092 cites W2019922184 @default.
• W1978187092 cites W2029667189 @default.
• W1978187092 cites W2035266068 @default.
• W1978187092 cites W2037961222 @default.
• W1978187092 cites W2038874580 @default.
• W1978187092 cites W2067174909 @default.
• W1978187092 cites W2070099193 @default.
• W1978187092 cites W2071195125 @default.
• W1978187092 cites W2071416115 @default.
• W1978187092 cites W2073623394 @default.
• W1978187092 cites W2074783201 @default.
• W1978187092 cites W2076087913 @default.
• W1978187092 cites W2079685391 @default.
• W1978187092 cites W2080255536 @default.
• W1978187092 cites W2087612874 @default.
• W1978187092 cites W2087799175 @default.
• W1978187092 cites W2089918014 @default.
• W1978187092 cites W2112154906 @default.
• W1978187092 cites W2121084043 @default.
• W1978187092 cites W2128572087 @default.
• W1978187092 cites W2138301928 @default.
• W1978187092 cites W2142364749 @default.
• W1978187092 cites W2146032902 @default.
• W1978187092 cites W2162272218 @default.
• W1978187092 cites W2170597887 @default.
• W1978187092 cites W2171268876 @default.
• W1978187092 cites W2225374532 @default.
• W1978187092 cites W2339536433 @default.
• W1978187092 cites W2400431145 @default.
• W1978187092 cites W2470655123 @default.
• W1978187092 cites W4236274105 @default.
• W1978187092 doi "https://doi.org/10.1371/journal.pone.0025747" @default.
• W1978187092 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3192114" @default.
• W1978187092 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22022441" @default.
• W1978187092 hasPublicationYear "2011" @default.
• W1978187092 type Work @default.
• W1978187092 sameAs 1978187092 @default.
• W1978187092 citedByCount "23" @default.
• W1978187092 countsByYear W19781870922012 @default.
• W1978187092 countsByYear W19781870922013 @default.
• W1978187092 countsByYear W19781870922014 @default.
• W1978187092 countsByYear W19781870922015 @default.
• W1978187092 countsByYear W19781870922016 @default.
• W1978187092 countsByYear W19781870922017 @default.
• W1978187092 countsByYear W19781870922018 @default.
• W1978187092 countsByYear W19781870922019 @default.
• W1978187092 countsByYear W19781870922020 @default.
• W1978187092 countsByYear W19781870922021 @default.
• W1978187092 countsByYear W19781870922022 @default.
• W1978187092 countsByYear W19781870922023 @default.
• W1978187092 crossrefType "journal-article" @default.
• W1978187092 hasAuthorship W1978187092A5013236796 @default.
• W1978187092 hasAuthorship W1978187092A5065578013 @default.
• W1978187092 hasAuthorship W1978187092A5066235342 @default.
• W1978187092 hasAuthorship W1978187092A5086388372 @default.
• W1978187092 hasBestOaLocation W19781870921 @default.
• W1978187092 hasConcept C104317684 @default.
• W1978187092 hasConcept C12554922 @default.
• W1978187092 hasConcept C134018914 @default.
• W1978187092 hasConcept C147597530 @default.
• W1978187092 hasConcept C149011108 @default.
• W1978187092 hasConcept C161573976 @default.
• W1978187092 hasConcept C185592680 @default.
• W1978187092 hasConcept C2776188179 @default.
• W1978187092 hasConcept C2777866211 @default.
• W1978187092 hasConcept C2779306644 @default.
• W1978187092 hasConcept C55493867 @default.
• W1978187092 hasConcept C57581600 @default.
• W1978187092 hasConcept C59593255 @default.
• W1978187092 hasConcept C86803240 @default.
• W1978187092 hasConcept C89200155 @default.

• next