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• W1978192005 abstract "Profile of ipilimumab and its role in the treatment of metastatic melanoma Sapna P Patel, Scott E WoodmanMelanoma Medical Oncology Department, University of Texas, MD Anderson Cancer Center, Houston, TX, USAAbstract: Melanoma is an immunogenic cancer. However, the ability of the immune system to eradicate melanoma tumors is affected by intrinsic negative regulatory mechanisms. Multiple immune-modulatory therapies are currently being developed to optimize the immune response to melanoma tumors. Two recent Phase III studies using the monoclonal antibody ipilimumab, which targets the cytotoxic T-lymphocyte antigen (CTLA-4), a negative regulator of T-cell activation, have demonstrated improvement in overall survival of metastatic melanoma patients. This review highlights the clinical trial data that supports the efficacy of ipilimumab, the immune-related response criteria used to evaluate clinical response, and side-effect profile associated with ipilimumab treatment.Keywords: ipilimumab, melanoma, T-cells, CTLA-4" @default.
• W1978192005 created "2016-06-24" @default.
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• W1978192005 date "2011-12-01" @default.
• W1978192005 modified "2023-09-28" @default.
• W1978192005 title "Profile of ipilimumab and its role in the treatment of metastatic melanoma" @default.
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• W1978192005 doi "https://doi.org/10.2147/dddt.s10945" @default.
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