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- W1978193003 abstract "Control of oral anticoagulation therapy has been reported to often be inadequate. Previous retrospective investigations suggest that patients' self-adjustment of oral anticoagulants may lead to improved control.To investigate the effects of patients' self-management of oral anticoagulation therapy on accuracy of control and measures of treatment-related quality of life.Randomized, single-blind, multicenter trial.A total of 179 patients receiving long-term oral anticoagulation treatment were enrolled at 5 referral centers in Germany.Patients were randomized to an oral anticoagulation self-management group based on a structured treatment and teaching program and international normalized ratio (INR) self-monitoring. The control group received conventional care as provided by family physicians, including referral to specialists if necessary.Deviation of INR values from the individual INR target range (squared) and the 5 categories of treatment-related quality of life.Deviation of INR value from the mean of the INR target range was significantly lower in the intervention group at 3-month (squared INR deviation, 0.59 vs 0.95; P<.001) and 6-month follow-up (0.65 vs 0.83; P=.03) compared with the control group. Also, the intervention group had INR values within the target range more often (repeated measurement analysis for categorical data, P=.006). The results were mainly due to less frequent suboptimal INR values in the intervention group (32.8% vs 50.0% [P=.03] at 3-month, and 33.7% vs 48.2% [P=.08] at 6-month follow-up). Treatment-related quality-of-life measures, especially treatment satisfaction scores, were significantly higher in the intervention group compared with controls.An anticoagulation education program that includes self-management of anticoagulation therapy results in improved accuracy of anticoagulation control and in treatment-related quality-of-life measures. Further studies are needed to describe whether the program will reduce risk of bleeding or thromboembolism." @default.
- W1978193003 created "2016-06-24" @default.
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- W1978193003 date "1999-01-13" @default.
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- W1978193003 title "A Structured Teaching and Self-management Program for Patients Receiving Oral Anticoagulation<SUBTITLE>A Randomized Controlled Trial</SUBTITLE>" @default.
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- W1978193003 doi "https://doi.org/10.1001/jama.281.2.145" @default.
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