Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978194636> ?p ?o ?g. }
- W1978194636 endingPage "486" @default.
- W1978194636 startingPage "476" @default.
- W1978194636 abstract "Abstract Patients with psoriasis, a chronic, hyperproliferative and noninfectious skin disease, suffer surprisingly fewer cutaneous infections than would be expected. This observation led us to the hypothesis that a local “chemical shield” in the form of antimicrobial proteins provides psoriatic skin with resistance against infection. We subsequently began a systematic analysis of in vitro antimicrobially active proteins in psoriatic-scale extracts. A biochemical approach with rigorous purification and characterization combined with antimicrobial testing identified a number of mostly new human antibiotic peptides and proteins. In this review, we will focus on the most prominent antimicrobial proteins in psoriatic-scale extracts, which we identified as the S100-protein psoriasin, human β-defensin 2 (hBD-2), RNase 7, lysozyme, and human neutrophil defensin 1–3. Apart from these cutaneous, antimicrobial proteins, only a few others, including hBD-3, have been characterized. A great number of minor antimicrobial proteins await further structural characterization." @default.
- W1978194636 created "2016-06-24" @default.
- W1978194636 creator A5027713095 @default.
- W1978194636 creator A5074088715 @default.
- W1978194636 date "2005-01-03" @default.
- W1978194636 modified "2023-10-18" @default.
- W1978194636 title "Psoriatic scales: a promising source for the isolation of human skin-derived antimicrobial proteins" @default.
- W1978194636 cites W1518421316 @default.
- W1978194636 cites W1571292455 @default.
- W1978194636 cites W1587808121 @default.
- W1978194636 cites W1588950918 @default.
- W1978194636 cites W1602448053 @default.
- W1978194636 cites W1604783437 @default.
- W1978194636 cites W1627442108 @default.
- W1978194636 cites W1662030037 @default.
- W1978194636 cites W1954606945 @default.
- W1978194636 cites W1964758221 @default.
- W1978194636 cites W1967059990 @default.
- W1978194636 cites W1972689531 @default.
- W1978194636 cites W1975904765 @default.
- W1978194636 cites W1979962636 @default.
- W1978194636 cites W1983987058 @default.
- W1978194636 cites W1984458030 @default.
- W1978194636 cites W1989428978 @default.
- W1978194636 cites W1990436439 @default.
- W1978194636 cites W1990519548 @default.
- W1978194636 cites W1997868832 @default.
- W1978194636 cites W2001439699 @default.
- W1978194636 cites W2008049824 @default.
- W1978194636 cites W2011807378 @default.
- W1978194636 cites W2013245073 @default.
- W1978194636 cites W2013621172 @default.
- W1978194636 cites W2018308291 @default.
- W1978194636 cites W2019132845 @default.
- W1978194636 cites W2020715272 @default.
- W1978194636 cites W2023617736 @default.
- W1978194636 cites W2026658988 @default.
- W1978194636 cites W2029331076 @default.
- W1978194636 cites W2030642888 @default.
- W1978194636 cites W2033113326 @default.
- W1978194636 cites W2035931280 @default.
- W1978194636 cites W2036124167 @default.
- W1978194636 cites W2045405814 @default.
- W1978194636 cites W2048131709 @default.
- W1978194636 cites W2049682225 @default.
- W1978194636 cites W2055382262 @default.
- W1978194636 cites W2056778526 @default.
- W1978194636 cites W2056879455 @default.
- W1978194636 cites W2056996834 @default.
- W1978194636 cites W2058608036 @default.
- W1978194636 cites W2063951978 @default.
- W1978194636 cites W2065067981 @default.
- W1978194636 cites W2065926489 @default.
- W1978194636 cites W2066456239 @default.
- W1978194636 cites W2069492069 @default.
- W1978194636 cites W2070464212 @default.
- W1978194636 cites W2073865475 @default.
- W1978194636 cites W2075158987 @default.
- W1978194636 cites W2079468421 @default.
- W1978194636 cites W2081407130 @default.
- W1978194636 cites W2081756009 @default.
- W1978194636 cites W2082780530 @default.
- W1978194636 cites W2083047852 @default.
- W1978194636 cites W2084175456 @default.
- W1978194636 cites W2085507541 @default.
- W1978194636 cites W2085793178 @default.
- W1978194636 cites W2090042814 @default.
- W1978194636 cites W2092663747 @default.
- W1978194636 cites W2093412162 @default.
- W1978194636 cites W2093717452 @default.
- W1978194636 cites W2094036101 @default.
- W1978194636 cites W2096263179 @default.
- W1978194636 cites W2104159258 @default.
- W1978194636 cites W2108792803 @default.
- W1978194636 cites W2110575428 @default.
- W1978194636 cites W2111926316 @default.
- W1978194636 cites W2112226410 @default.
- W1978194636 cites W2116627464 @default.
- W1978194636 cites W2120124319 @default.
- W1978194636 cites W2121580723 @default.
- W1978194636 cites W2123579792 @default.
- W1978194636 cites W2125347897 @default.
- W1978194636 cites W2126636554 @default.
- W1978194636 cites W2134326405 @default.
- W1978194636 cites W2136538608 @default.
- W1978194636 cites W2140816250 @default.
- W1978194636 cites W2143996485 @default.
- W1978194636 cites W2144599944 @default.
- W1978194636 cites W2145268435 @default.
- W1978194636 cites W2146549712 @default.
- W1978194636 cites W2146871130 @default.
- W1978194636 cites W2148067829 @default.
- W1978194636 cites W2149794110 @default.
- W1978194636 cites W2158299121 @default.
- W1978194636 cites W2161524185 @default.
- W1978194636 cites W2162488580 @default.
- W1978194636 cites W2163665267 @default.
- W1978194636 cites W2164206375 @default.