Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978195655> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W1978195655 endingPage "e41009" @default.
- W1978195655 startingPage "e41009" @default.
- W1978195655 abstract "The enormous bacterial load and mechanical forces in colon create a special requirement for protection of the epithelium. In the distal colon, this problem is largely solved by separation of the bacteria from the epithelium by a firmly attached inner mucus layer. In addition, an outer mucus layer entraps bacteria to be cleared by distal transport. The mucus layers contain a network of Muc2 mucins as the main structural component. Here, the renewal rate of the inner protective mucus layer was studied as well as the production and secretion of Muc2 mucin in the distal colon. This was performed by intraperitoneal injection of N-azidoacetyl-galactosamine (GalNAz) that was in vivo incorporated during biosynthesis of O-glycosylated glycoproteins. The only gel-forming mucin produced in the colon is the Muc2 mucin and as it carries numerous O-glycans, the granulae of the goblet cells producing Muc2 mucin were intensely stained. The GalNAz-labeled glycoproteins were first observed in the Golgi apparatus of most cells. Goblet cells in the luminal surface epithelium had the fastest biosynthesis of Muc2 and secreted material already three hours after labeling. This secreted GalNAz-labeled Muc2 mucin formed the inner mucus layer. The goblet cells along the crypt epithelium accumulated labeled mucin vesicles for a longer period and secretion of labeled Muc2 mucin was first observed after 6 to 8 h. This study reveals a fast turnover (1 h) of the inner mucus layer in the distal colon mediated by goblet cells of the luminal surface epithelium." @default.
- W1978195655 created "2016-06-24" @default.
- W1978195655 creator A5030770974 @default.
- W1978195655 date "2012-07-17" @default.
- W1978195655 modified "2023-09-30" @default.
- W1978195655 title "Fast Renewal of the Distal Colonic Mucus Layers by the Surface Goblet Cells as Measured by In Vivo Labeling of Mucin Glycoproteins" @default.
- W1978195655 cites W1967019999 @default.
- W1978195655 cites W1967217097 @default.
- W1978195655 cites W1995420663 @default.
- W1978195655 cites W2009304941 @default.
- W1978195655 cites W2023912458 @default.
- W1978195655 cites W2030364983 @default.
- W1978195655 cites W2031558979 @default.
- W1978195655 cites W2042488865 @default.
- W1978195655 cites W2048470673 @default.
- W1978195655 cites W2061787159 @default.
- W1978195655 cites W2080466925 @default.
- W1978195655 cites W2099684879 @default.
- W1978195655 cites W2118002029 @default.
- W1978195655 doi "https://doi.org/10.1371/journal.pone.0041009" @default.
- W1978195655 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3398881" @default.
- W1978195655 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22815896" @default.
- W1978195655 hasPublicationYear "2012" @default.
- W1978195655 type Work @default.
- W1978195655 sameAs 1978195655 @default.
- W1978195655 citedByCount "153" @default.
- W1978195655 countsByYear W19781956552013 @default.
- W1978195655 countsByYear W19781956552014 @default.
- W1978195655 countsByYear W19781956552015 @default.
- W1978195655 countsByYear W19781956552016 @default.
- W1978195655 countsByYear W19781956552017 @default.
- W1978195655 countsByYear W19781956552018 @default.
- W1978195655 countsByYear W19781956552019 @default.
- W1978195655 countsByYear W19781956552020 @default.
- W1978195655 countsByYear W19781956552021 @default.
- W1978195655 countsByYear W19781956552022 @default.
- W1978195655 countsByYear W19781956552023 @default.
- W1978195655 crossrefType "journal-article" @default.
- W1978195655 hasAuthorship W1978195655A5030770974 @default.
- W1978195655 hasBestOaLocation W19781956551 @default.
- W1978195655 hasConcept C104317684 @default.
- W1978195655 hasConcept C108625454 @default.
- W1978195655 hasConcept C150194340 @default.
- W1978195655 hasConcept C179264091 @default.
- W1978195655 hasConcept C185592680 @default.
- W1978195655 hasConcept C18903297 @default.
- W1978195655 hasConcept C2775941134 @default.
- W1978195655 hasConcept C2777116383 @default.
- W1978195655 hasConcept C2777312293 @default.
- W1978195655 hasConcept C49039625 @default.
- W1978195655 hasConcept C529295009 @default.
- W1978195655 hasConcept C54355233 @default.
- W1978195655 hasConcept C55493867 @default.
- W1978195655 hasConcept C86803240 @default.
- W1978195655 hasConcept C95444343 @default.
- W1978195655 hasConceptScore W1978195655C104317684 @default.
- W1978195655 hasConceptScore W1978195655C108625454 @default.
- W1978195655 hasConceptScore W1978195655C150194340 @default.
- W1978195655 hasConceptScore W1978195655C179264091 @default.
- W1978195655 hasConceptScore W1978195655C185592680 @default.
- W1978195655 hasConceptScore W1978195655C18903297 @default.
- W1978195655 hasConceptScore W1978195655C2775941134 @default.
- W1978195655 hasConceptScore W1978195655C2777116383 @default.
- W1978195655 hasConceptScore W1978195655C2777312293 @default.
- W1978195655 hasConceptScore W1978195655C49039625 @default.
- W1978195655 hasConceptScore W1978195655C529295009 @default.
- W1978195655 hasConceptScore W1978195655C54355233 @default.
- W1978195655 hasConceptScore W1978195655C55493867 @default.
- W1978195655 hasConceptScore W1978195655C86803240 @default.
- W1978195655 hasConceptScore W1978195655C95444343 @default.
- W1978195655 hasIssue "7" @default.
- W1978195655 hasLocation W19781956551 @default.
- W1978195655 hasLocation W19781956552 @default.
- W1978195655 hasLocation W19781956553 @default.
- W1978195655 hasLocation W19781956554 @default.
- W1978195655 hasOpenAccess W1978195655 @default.
- W1978195655 hasPrimaryLocation W19781956551 @default.
- W1978195655 hasRelatedWork W1542850324 @default.
- W1978195655 hasRelatedWork W1947786813 @default.
- W1978195655 hasRelatedWork W1972212283 @default.
- W1978195655 hasRelatedWork W1978195655 @default.
- W1978195655 hasRelatedWork W2043407591 @default.
- W1978195655 hasRelatedWork W2077452200 @default.
- W1978195655 hasRelatedWork W2109173245 @default.
- W1978195655 hasRelatedWork W3080848845 @default.
- W1978195655 hasRelatedWork W4210507399 @default.
- W1978195655 hasRelatedWork W4293820935 @default.
- W1978195655 hasVolume "7" @default.
- W1978195655 isParatext "false" @default.
- W1978195655 isRetracted "false" @default.
- W1978195655 magId "1978195655" @default.
- W1978195655 workType "article" @default.