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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978196348> ?p ?o ?g. }

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• W1978196348 abstract "The search for new and improved antipsychotic agents has escalated during the past five years. The era of searching for non-toxic copies of clozapine has been followed by several different lines of research, some of which pursue the traditional dopamine track, although at a higher level of sophistication, whereas others focus on other neurotransmitters, such as serotonin and glutamate. Emerging knowledge about the interactions between different neurotransmitters in complex neurocircuits opens up possibilities for achieving antipsychotic activity by interfering with many different neurotransmitters. Most intriguing is the finding in animal experimental models, indicating that it should be possible to alleviate psychotic conditions by stabilizing rather than paralyzing neurocircuits, thus avoiding the risk of motor and mental side effects of the currently used drugs. Among these new classes dopaminergic stabilizers and 5-HT2A receptor antagonists seem to offer most promise at present. In a longer perspective, drugs interfering with glutamate function via different mechanisms may also turn out to be useful, especially in the control of negative symptoms." @default.
• W1978196348 created "2016-06-24" @default.
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• W1978196348 date "1999-11-01" @default.
• W1978196348 modified "2023-10-17" @default.
• W1978196348 title "Neurotransmitter interactions in schizophrenia—therapeutic implications" @default.
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• W1978196348 doi "https://doi.org/10.1016/s0006-3223(99)00117-1" @default.
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