Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978196673> ?p ?o ?g. }
- W1978196673 endingPage "492" @default.
- W1978196673 startingPage "485" @default.
- W1978196673 abstract "To understand the relationship of viral load (VL), CD4 counts, and highly active antiretroviral therapy (HAART) use to health-related quality of life (HRQL).Cross-sectional analysis of 513 HIV-infected patients. Primary outcomes were four domains of HRQL: physical functioning (PF), role function (RF), energy levels (EL), and health perceptions (HP). The authors examined univariate and multivariate relationships between VL, CD4, and HAART use to each HRQL domain, after adjustment for potential confounders.In univariate analyses, compared with patients with CD4 > 500, those with CD4 < 200 (p =.001) or 200 to 500 (p =.002) had lower PF and RF scores, and patients with undetectable VL had higher PF scores than patients with VL log10 2.6 to 4.0 (p =.02) and > log10 4.0 (p =.01). In multivariate analyses, compared with patients with CD4 > 500, patients with CD4 < 200 had lower PF (-8.8 points; p <.01), RF (-9.3 points; p <.01), and HP (-7.8 points; p <.001). Patients with log10 VL 2.6 to 4.0 had lower PF scores (-7.7 points; p <.01) versus undetectable VL. After adjusting for VL and CD4 counts, HAART use was associated with lower PF scores (-5.4 points; p <.05).Efforts to improve patients' CD4 counts are likely to also improve HRQL. Lowering viral loads may improve physical functioning, but only if VL are suppressed to undetectable levels. In this analysis, HAART had negative effects on PF that were independent of its effects on CD4 and VL. For adherent patients, these adverse effects of HAART on PF are likely to be outweighed by the positive effects that HAART exerts through lowering VL and increasing CD4 counts." @default.
- W1978196673 created "2016-06-24" @default.
- W1978196673 creator A5012844786 @default.
- W1978196673 creator A5029271602 @default.
- W1978196673 creator A5042929688 @default.
- W1978196673 creator A5057005316 @default.
- W1978196673 creator A5080542025 @default.
- W1978196673 creator A5091240180 @default.
- W1978196673 date "2002-08-01" @default.
- W1978196673 modified "2023-09-26" @default.
- W1978196673 title "Relationship of HIV Viral Loads, CD4 Counts, and HAART Use to Health-Related Quality of Life" @default.
- W1978196673 cites W1544148090 @default.
- W1978196673 cites W1966416156 @default.
- W1978196673 cites W1987445308 @default.
- W1978196673 cites W1996025409 @default.
- W1978196673 cites W1997808475 @default.
- W1978196673 cites W2007823736 @default.
- W1978196673 cites W2012139740 @default.
- W1978196673 cites W2012454301 @default.
- W1978196673 cites W2016934692 @default.
- W1978196673 cites W2069838997 @default.
- W1978196673 cites W2073302587 @default.
- W1978196673 cites W2107628029 @default.
- W1978196673 cites W2122066587 @default.
- W1978196673 cites W2126313264 @default.
- W1978196673 cites W2171141994 @default.
- W1978196673 cites W2316456037 @default.
- W1978196673 cites W2324816636 @default.
- W1978196673 cites W2328689632 @default.
- W1978196673 cites W2335592397 @default.
- W1978196673 cites W2340113298 @default.
- W1978196673 cites W4235768531 @default.
- W1978196673 cites W4246147341 @default.
- W1978196673 doi "https://doi.org/10.1097/00126334-200208150-00004" @default.
- W1978196673 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12154339" @default.
- W1978196673 hasPublicationYear "2002" @default.
- W1978196673 type Work @default.
- W1978196673 sameAs 1978196673 @default.
- W1978196673 citedByCount "103" @default.
- W1978196673 countsByYear W19781966732012 @default.
- W1978196673 countsByYear W19781966732013 @default.
- W1978196673 countsByYear W19781966732014 @default.
- W1978196673 countsByYear W19781966732015 @default.
- W1978196673 countsByYear W19781966732016 @default.
- W1978196673 countsByYear W19781966732017 @default.
- W1978196673 countsByYear W19781966732018 @default.
- W1978196673 countsByYear W19781966732019 @default.
- W1978196673 countsByYear W19781966732020 @default.
- W1978196673 countsByYear W19781966732021 @default.
- W1978196673 countsByYear W19781966732022 @default.
- W1978196673 countsByYear W19781966732023 @default.
- W1978196673 crossrefType "journal-article" @default.
- W1978196673 hasAuthorship W1978196673A5012844786 @default.
- W1978196673 hasAuthorship W1978196673A5029271602 @default.
- W1978196673 hasAuthorship W1978196673A5042929688 @default.
- W1978196673 hasAuthorship W1978196673A5057005316 @default.
- W1978196673 hasAuthorship W1978196673A5080542025 @default.
- W1978196673 hasAuthorship W1978196673A5091240180 @default.
- W1978196673 hasBestOaLocation W19781966731 @default.
- W1978196673 hasConcept C126322002 @default.
- W1978196673 hasConcept C142052008 @default.
- W1978196673 hasConcept C142462285 @default.
- W1978196673 hasConcept C142724271 @default.
- W1978196673 hasConcept C144301174 @default.
- W1978196673 hasConcept C159110408 @default.
- W1978196673 hasConcept C197934379 @default.
- W1978196673 hasConcept C203014093 @default.
- W1978196673 hasConcept C2779951463 @default.
- W1978196673 hasConcept C3013748606 @default.
- W1978196673 hasConcept C38180746 @default.
- W1978196673 hasConcept C71924100 @default.
- W1978196673 hasConcept C77350462 @default.
- W1978196673 hasConcept C90924648 @default.
- W1978196673 hasConceptScore W1978196673C126322002 @default.
- W1978196673 hasConceptScore W1978196673C142052008 @default.
- W1978196673 hasConceptScore W1978196673C142462285 @default.
- W1978196673 hasConceptScore W1978196673C142724271 @default.
- W1978196673 hasConceptScore W1978196673C144301174 @default.
- W1978196673 hasConceptScore W1978196673C159110408 @default.
- W1978196673 hasConceptScore W1978196673C197934379 @default.
- W1978196673 hasConceptScore W1978196673C203014093 @default.
- W1978196673 hasConceptScore W1978196673C2779951463 @default.
- W1978196673 hasConceptScore W1978196673C3013748606 @default.
- W1978196673 hasConceptScore W1978196673C38180746 @default.
- W1978196673 hasConceptScore W1978196673C71924100 @default.
- W1978196673 hasConceptScore W1978196673C77350462 @default.
- W1978196673 hasConceptScore W1978196673C90924648 @default.
- W1978196673 hasIssue "5" @default.
- W1978196673 hasLocation W19781966731 @default.
- W1978196673 hasLocation W19781966732 @default.
- W1978196673 hasLocation W19781966733 @default.
- W1978196673 hasOpenAccess W1978196673 @default.
- W1978196673 hasPrimaryLocation W19781966731 @default.
- W1978196673 hasRelatedWork W1973460911 @default.
- W1978196673 hasRelatedWork W1978196673 @default.
- W1978196673 hasRelatedWork W1999404209 @default.
- W1978196673 hasRelatedWork W2038607597 @default.
- W1978196673 hasRelatedWork W2096903645 @default.