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• W1978199085 abstract "When right ventricular ejection time and RV pre-ejection period are measured from the pulmonary valve echocardiogram, a RPEP/RVET ratio greater than 0.35 has been associated with increased pulmonary vascular resistance. Four children with alveolar hypoventilation secondary to enlarged tonsils and adenoids, or Pierre Robin syndrome with microlarynx, were studied. Onset of upper airway obstruction ranged from birth to 2½ years of age. The patients had a decreased PaO2 (39 to 60 mm Hg), elevated PaCO2 (50 to 60 mm Hg) during sleep, right atrial and right ventricular hypertrophy by electrocardiogram, and cardiomegaly by roentgenogram. Pulmonary artery pressures during cardiac catheterization ranged from 75/40 (m = 65) to 100/50 (m = 70) and RPEP/RVET was greater than 0.5 in each child (normal 0.24 ± 0.06). One patient, who was not catheterized, had an RPEP/RVET of 0.37. Oxygen administration or intubation during cardiac catheterization reduced PAP to 40/10 (m = 30) and 50/10 (m = 30), respectively, in two patients, and RPEP/RVET decreased simultaneously to less than 0.3. Three children underwent tonsillectomy and/or adenoidectomy and one child had tracheostomy. RPEP/RVET decreased postoperatively to less than 0.31 in all patients. Sleep arterial blood gas values, ECG, and chest roentgenogram also reverted to normal. When right ventricular ejection time and RV pre-ejection period are measured from the pulmonary valve echocardiogram, a RPEP/RVET ratio greater than 0.35 has been associated with increased pulmonary vascular resistance. Four children with alveolar hypoventilation secondary to enlarged tonsils and adenoids, or Pierre Robin syndrome with microlarynx, were studied. Onset of upper airway obstruction ranged from birth to 2½ years of age. The patients had a decreased PaO2 (39 to 60 mm Hg), elevated PaCO2 (50 to 60 mm Hg) during sleep, right atrial and right ventricular hypertrophy by electrocardiogram, and cardiomegaly by roentgenogram. Pulmonary artery pressures during cardiac catheterization ranged from 75/40 (m = 65) to 100/50 (m = 70) and RPEP/RVET was greater than 0.5 in each child (normal 0.24 ± 0.06). One patient, who was not catheterized, had an RPEP/RVET of 0.37. Oxygen administration or intubation during cardiac catheterization reduced PAP to 40/10 (m = 30) and 50/10 (m = 30), respectively, in two patients, and RPEP/RVET decreased simultaneously to less than 0.3. Three children underwent tonsillectomy and/or adenoidectomy and one child had tracheostomy. RPEP/RVET decreased postoperatively to less than 0.31 in all patients. Sleep arterial blood gas values, ECG, and chest roentgenogram also reverted to normal." @default.
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• W1978199085 date "1978-12-01" @default.
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• W1978199085 title "Echocardiographic changes in children with pulmonary hypertension secondary to upper airway obstruction" @default.
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• W1978199085 doi "https://doi.org/10.1016/s0022-3476(78)81214-1" @default.
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