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- W1978200313 abstract "The MMPI [14C]ABT-770 (1), N-[(1S)-1-[(4,4-Dimethyl-2,5-dioxo-1-imi-dazolidinyl)methyl]]-2-[[4′-(trifluoromethoxy)[1,1′-biphenyl]-4-yl]oxy]ethyl]-N-hydroxyformamide was synthesized in 8 steps using 4-bromophenol-UL-14C (10) as a starting material. The Carbon-14 label was introduced in one of the metabolically stable biphenyl rings. The key sequence of the synthesis was a three-step one-pot reaction in which the hydantoin moiety was introduced, the imine oxidized and further hydrolyzed to get the penultimate precursor to [14C]ABT-770 (1) in 56% yield. Copyright © 2003 John Wiley & Sons, Ltd." @default.
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- W1978200313 date "2003-01-01" @default.
- W1978200313 modified "2023-09-26" @default.
- W1978200313 title "Synthesis of [14C]ABT-770, matrix metalloproteinase inhibitor (MMPI), labelled in the phenoxy ring" @default.
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- W1978200313 doi "https://doi.org/10.1002/jlcr.727" @default.
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