FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978201430> ?p ?o ?g. }

• W1978201430 endingPage "1122" @default.
• W1978201430 startingPage "1115" @default.
• W1978201430 abstract "The mTOR pathway is a well-known regulator of cell size, and deregulation of mTOR has been observed in cilia-related diseases. Cilia modulate cell size by restricting LKB-1-mediated activation of AMPK to the basal body, which subsequently affects mTOR signalling. The mTOR pathway is the central regulator of cell size1. External signals from growth factors and nutrients converge on the mTORC1 multi-protein complex to modulate downstream targets, but how the different inputs are integrated and translated into specific cellular responses is incompletely understood2,3,4. Deregulation of the mTOR pathway occurs in polycystic kidney disease (PKD)5,6,7, where cilia (filiform sensory organelles) fail to sense urine flow because of inherited mutations in ciliary proteins8. We therefore investigated if cilia have a role in mTOR regulation. Here, we show that ablation of cilia in transgenic mice results in enlarged cells when compared with control animals. In vitro analysis demonstrated that bending of the cilia by flow is required for mTOR downregulation and cell-size control. Surprisingly, regulation of cell size by cilia is independent of flow-induced calcium transients, or Akt. However, the tumour-suppressor protein Lkb1 localises in the cilium, and flow results in increased AMPK phosphorylation at the basal body. Conversely, knockdown of Lkb1 prevents normal cell-size regulation under flow conditions. Our results demonstrate that the cilium regulates mTOR signalling and cell size, and identify the cilium-basal body compartment as a spatially restricted activation site for Lkb1 signalling." @default.
• W1978201430 created "2016-06-24" @default.
• W1978201430 creator A5015436238 @default.
• W1978201430 creator A5024059133 @default.
• W1978201430 creator A5028196682 @default.
• W1978201430 creator A5029050013 @default.
• W1978201430 creator A5033802517 @default.
• W1978201430 creator A5034115514 @default.
• W1978201430 creator A5039063866 @default.
• W1978201430 creator A5039685807 @default.
• W1978201430 creator A5042022474 @default.
• W1978201430 creator A5044945443 @default.
• W1978201430 creator A5048410197 @default.
• W1978201430 creator A5049382233 @default.
• W1978201430 creator A5051480903 @default.
• W1978201430 creator A5059096252 @default.
• W1978201430 creator A5059941792 @default.
• W1978201430 creator A5063313893 @default.
• W1978201430 creator A5065751752 @default.
• W1978201430 creator A5083795868 @default.
• W1978201430 creator A5088452330 @default.
• W1978201430 date "2010-10-24" @default.
• W1978201430 modified "2023-09-30" @default.
• W1978201430 title "Primary cilia regulate mTORC1 activity and cell size through Lkb1" @default.
• W1978201430 cites W162961686 @default.
• W1978201430 cites W1962669878 @default.
• W1978201430 cites W1964935836 @default.
• W1978201430 cites W1968484082 @default.
• W1978201430 cites W1971060771 @default.
• W1978201430 cites W1974601240 @default.
• W1978201430 cites W1986175901 @default.
• W1978201430 cites W1997053429 @default.
• W1978201430 cites W1999095798 @default.
• W1978201430 cites W2002226709 @default.
• W1978201430 cites W2006559495 @default.
• W1978201430 cites W2015616869 @default.
• W1978201430 cites W2023012828 @default.
• W1978201430 cites W2028607959 @default.
• W1978201430 cites W2032792789 @default.
• W1978201430 cites W2047750288 @default.
• W1978201430 cites W2053094829 @default.
• W1978201430 cites W2063092306 @default.
• W1978201430 cites W2063201880 @default.
• W1978201430 cites W2072300370 @default.
• W1978201430 cites W2082060108 @default.
• W1978201430 cites W2089807404 @default.
• W1978201430 cites W2094941511 @default.
• W1978201430 cites W2095081144 @default.
• W1978201430 cites W2095869636 @default.
• W1978201430 cites W2097651960 @default.
• W1978201430 cites W2108902166 @default.
• W1978201430 cites W2123046057 @default.
• W1978201430 cites W2123700457 @default.
• W1978201430 cites W2124802842 @default.
• W1978201430 cites W2134138119 @default.
• W1978201430 cites W2137559718 @default.
• W1978201430 cites W2137662644 @default.
• W1978201430 cites W2141331673 @default.
• W1978201430 cites W2143112776 @default.
• W1978201430 cites W2148407960 @default.
• W1978201430 cites W2152072269 @default.
• W1978201430 cites W2152198679 @default.
• W1978201430 cites W2154261437 @default.
• W1978201430 cites W2154820433 @default.
• W1978201430 cites W2164489472 @default.
• W1978201430 cites W2166754647 @default.
• W1978201430 cites W2169520827 @default.
• W1978201430 cites W2169980814 @default.
• W1978201430 doi "https://doi.org/10.1038/ncb2117" @default.
• W1978201430 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3390256" @default.
• W1978201430 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20972424" @default.
• W1978201430 hasPublicationYear "2010" @default.
• W1978201430 type Work @default.
• W1978201430 sameAs 1978201430 @default.
• W1978201430 citedByCount "316" @default.
• W1978201430 countsByYear W19782014302012 @default.
• W1978201430 countsByYear W19782014302013 @default.
• W1978201430 countsByYear W19782014302014 @default.
• W1978201430 countsByYear W19782014302015 @default.
• W1978201430 countsByYear W19782014302016 @default.
• W1978201430 countsByYear W19782014302017 @default.
• W1978201430 countsByYear W19782014302018 @default.
• W1978201430 countsByYear W19782014302019 @default.
• W1978201430 countsByYear W19782014302020 @default.
• W1978201430 countsByYear W19782014302021 @default.
• W1978201430 countsByYear W19782014302022 @default.
• W1978201430 countsByYear W19782014302023 @default.
• W1978201430 crossrefType "journal-article" @default.
• W1978201430 hasAuthorship W1978201430A5015436238 @default.
• W1978201430 hasAuthorship W1978201430A5024059133 @default.
• W1978201430 hasAuthorship W1978201430A5028196682 @default.
• W1978201430 hasAuthorship W1978201430A5029050013 @default.
• W1978201430 hasAuthorship W1978201430A5033802517 @default.
• W1978201430 hasAuthorship W1978201430A5034115514 @default.
• W1978201430 hasAuthorship W1978201430A5039063866 @default.
• W1978201430 hasAuthorship W1978201430A5039685807 @default.
• W1978201430 hasAuthorship W1978201430A5042022474 @default.
• W1978201430 hasAuthorship W1978201430A5044945443 @default.

• next