FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978202084> ?p ?o ?g. }

• W1978202084 endingPage "1642" @default.
• W1978202084 startingPage "1638" @default.
• W1978202084 abstract "To assess the influence of high extracellular glucose on the expression of the bone morphogenetic protein (BMP) antagonist, gremlin, in cultured bovine retinal pericytes (BRPC).BRPC were cultured under conditions of 5 mM and 30 mM d-glucose for 7 days and total RNA was isolated. Gremlin mRNA levels were correlated, by RT-PCR, with other genes implicated in the pathogenesis of diabetic retinopathy and the signalling pathways in high glucose induced gremlin expression were probed using physiological inhibitors. Gremlin expression was also examined in the retina of streptozotocin induced diabetic mice.High glucose stimulated a striking increase in BRPC gremlin mRNA levels in parallel with increases in mRNA for the growth factors vascular endothelial growth factor (VEGF), transforming growth factor beta (TGFbeta), and connective tissue growth factor (CTGF) and changes in other genes including fibronectin and plasminogen activator inhibitor-1 (PAI-1). High glucose triggered gremlin expression was modulated by anti-TGFbeta antibody, by the uncoupler of oxidative phosphorylation, CCCP, and by inhibition of MAP-kinase (MAPK) activation. Striking gremlin expression was observed in the outer retina of diabetic mice and also at the level of the vascular wall.Gremlin gene expression is induced in BRPC in response to elevated glucose and in the retina of the streptozotocin induced diabetic mouse. Its expression is modulated by hyperglycaemic induction of the MAPK, reactive oxygen species, and TGFbeta pathways, all of which are reported to have a role in diabetic fibrotic disease. This implicates a role for gremlin in the pathogenesis of diabetic retinopathy." @default.
• W1978202084 created "2016-06-24" @default.
• W1978202084 creator A5005391044 @default.
• W1978202084 creator A5025321891 @default.
• W1978202084 creator A5063656484 @default.
• W1978202084 creator A5065684610 @default.
• W1978202084 creator A5090729869 @default.
• W1978202084 date "2005-12-01" @default.
• W1978202084 modified "2023-10-06" @default.
• W1978202084 title "Gremlin gene expression in bovine retinal pericytes exposed to elevated glucose" @default.
• W1978202084 cites W1529592271 @default.
• W1978202084 cites W1565817365 @default.
• W1978202084 cites W157692930 @default.
• W1978202084 cites W163416440 @default.
• W1978202084 cites W1755902553 @default.
• W1978202084 cites W1779045446 @default.
• W1978202084 cites W1870327063 @default.
• W1978202084 cites W1971915141 @default.
• W1978202084 cites W1972890803 @default.
• W1978202084 cites W1976442335 @default.
• W1978202084 cites W1985432260 @default.
• W1978202084 cites W1992829978 @default.
• W1978202084 cites W1995861596 @default.
• W1978202084 cites W1998539941 @default.
• W1978202084 cites W2000227520 @default.
• W1978202084 cites W2001109862 @default.
• W1978202084 cites W2008213605 @default.
• W1978202084 cites W2010155782 @default.
• W1978202084 cites W2023090575 @default.
• W1978202084 cites W2030790832 @default.
• W1978202084 cites W2033771065 @default.
• W1978202084 cites W2042470405 @default.
• W1978202084 cites W2044384686 @default.
• W1978202084 cites W2044437167 @default.
• W1978202084 cites W2049648184 @default.
• W1978202084 cites W2054731255 @default.
• W1978202084 cites W2055043387 @default.
• W1978202084 cites W2057572435 @default.
• W1978202084 cites W2072603644 @default.
• W1978202084 cites W2077370871 @default.
• W1978202084 cites W2078283905 @default.
• W1978202084 cites W2092671785 @default.
• W1978202084 cites W2101819982 @default.
• W1978202084 cites W2108337314 @default.
• W1978202084 cites W2115420079 @default.
• W1978202084 cites W2115515762 @default.
• W1978202084 cites W2120172922 @default.
• W1978202084 cites W2129228358 @default.
• W1978202084 cites W2140462742 @default.
• W1978202084 cites W2143027219 @default.
• W1978202084 cites W2153913481 @default.
• W1978202084 cites W2161736514 @default.
• W1978202084 cites W2162396660 @default.
• W1978202084 cites W2302447233 @default.
• W1978202084 cites W2322846418 @default.
• W1978202084 cites W2419458309 @default.
• W1978202084 cites W2769264260 @default.
• W1978202084 cites W4229620401 @default.
• W1978202084 doi "https://doi.org/10.1136/bjo.2005.069591" @default.
• W1978202084 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1772980" @default.
• W1978202084 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16299147" @default.
• W1978202084 hasPublicationYear "2005" @default.
• W1978202084 type Work @default.
• W1978202084 sameAs 1978202084 @default.
• W1978202084 citedByCount "39" @default.
• W1978202084 countsByYear W19782020842012 @default.
• W1978202084 countsByYear W19782020842013 @default.
• W1978202084 countsByYear W19782020842014 @default.
• W1978202084 countsByYear W19782020842015 @default.
• W1978202084 countsByYear W19782020842016 @default.
• W1978202084 countsByYear W19782020842017 @default.
• W1978202084 countsByYear W19782020842018 @default.
• W1978202084 countsByYear W19782020842019 @default.
• W1978202084 countsByYear W19782020842020 @default.
• W1978202084 countsByYear W19782020842022 @default.
• W1978202084 countsByYear W19782020842023 @default.
• W1978202084 crossrefType "journal-article" @default.
• W1978202084 hasAuthorship W1978202084A5005391044 @default.
• W1978202084 hasAuthorship W1978202084A5025321891 @default.
• W1978202084 hasAuthorship W1978202084A5063656484 @default.
• W1978202084 hasAuthorship W1978202084A5065684610 @default.
• W1978202084 hasAuthorship W1978202084A5090729869 @default.
• W1978202084 hasBestOaLocation W19782020841 @default.
• W1978202084 hasConcept C126322002 @default.
• W1978202084 hasConcept C134018914 @default.
• W1978202084 hasConcept C146285616 @default.
• W1978202084 hasConcept C167734588 @default.
• W1978202084 hasConcept C169760540 @default.
• W1978202084 hasConcept C170493617 @default.
• W1978202084 hasConcept C2775960820 @default.
• W1978202084 hasConcept C2777025900 @default.
• W1978202084 hasConcept C2777093970 @default.
• W1978202084 hasConcept C2779679481 @default.
• W1978202084 hasConcept C2779829184 @default.
• W1978202084 hasConcept C2780631158 @default.
• W1978202084 hasConcept C2780675426 @default.
• W1978202084 hasConcept C2780827179 @default.
• W1978202084 hasConcept C55493867 @default.

• next