Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978210902> ?p ?o ?g. }
- W1978210902 endingPage "1121" @default.
- W1978210902 startingPage "1107" @default.
- W1978210902 abstract "The fem-1 gene of C. elegans is one of three genes required for all aspects of male development in the nematode. Current models of sex determination propose that the products of the fem genes act in a novel signal-transduction pathway and that their activity is regulated primarily at the post-translational level in somatic tissues. We analyzed the expression of fem-1 to determine whether it revealed any additional levels of regulation. Both XX hermaphrodites and XO males express fem-1 at approximately constant levels throughout development. Somatic tissues in hermaphrodites adopt female fates, but they nonetheless express fem-1 mRNA and FEM-1 protein, suggesting that the regulation of fem-1 activity is post-transcriptional and probably post-translational. A compact promoter directs functional expression of fem-1 transgenes, as assayed by their masculinizing activity in fem-1 mutants. Activity also requires any two or more introns, suggesting that splicing may enhance fem-1 expression. The minimal noncoding sequences required for activity of fem-1 transgenes suffice to direct expression of a fem-1::lacZ reporter gene in all somatic tissues in both sexes. Many fem-1 transgenes, including those that rescue male somatic development in fem-1 mutants, paradoxically feminize the germline. We suggest that they do so by interfering with the germline expression of the endogenous fem-1 gene." @default.
- W1978210902 created "2016-06-24" @default.
- W1978210902 creator A5037354090 @default.
- W1978210902 creator A5042287782 @default.
- W1978210902 creator A5007342674 @default.
- W1978210902 date "1996-07-01" @default.
- W1978210902 modified "2023-09-27" @default.
- W1978210902 title "Post-transcriptional regulation of sex determination in Caenorhabditis elegans: widespread expression of the sex-determining gene fem-1 in both sexes." @default.
- W1978210902 cites W1649971717 @default.
- W1978210902 cites W171906849 @default.
- W1978210902 cites W1756647715 @default.
- W1978210902 cites W1759413280 @default.
- W1978210902 cites W1870738472 @default.
- W1978210902 cites W1873199501 @default.
- W1978210902 cites W1873782865 @default.
- W1978210902 cites W1917287502 @default.
- W1978210902 cites W1940712597 @default.
- W1978210902 cites W1944127002 @default.
- W1978210902 cites W1948560580 @default.
- W1978210902 cites W1970689230 @default.
- W1978210902 cites W1971291306 @default.
- W1978210902 cites W1973706463 @default.
- W1978210902 cites W1977416599 @default.
- W1978210902 cites W1986006829 @default.
- W1978210902 cites W1989420807 @default.
- W1978210902 cites W1989952069 @default.
- W1978210902 cites W1990767061 @default.
- W1978210902 cites W1992678804 @default.
- W1978210902 cites W1997105434 @default.
- W1978210902 cites W2000838795 @default.
- W1978210902 cites W2002879092 @default.
- W1978210902 cites W2003633314 @default.
- W1978210902 cites W2005983458 @default.
- W1978210902 cites W2013460786 @default.
- W1978210902 cites W2017123363 @default.
- W1978210902 cites W2019166622 @default.
- W1978210902 cites W2030937967 @default.
- W1978210902 cites W2036155471 @default.
- W1978210902 cites W2036895244 @default.
- W1978210902 cites W2036931150 @default.
- W1978210902 cites W2041554842 @default.
- W1978210902 cites W2043177918 @default.
- W1978210902 cites W2043481572 @default.
- W1978210902 cites W2044032739 @default.
- W1978210902 cites W2047133971 @default.
- W1978210902 cites W2057241729 @default.
- W1978210902 cites W2057913897 @default.
- W1978210902 cites W2062883594 @default.
- W1978210902 cites W2066617620 @default.
- W1978210902 cites W2068465378 @default.
- W1978210902 cites W2076751679 @default.
- W1978210902 cites W2079377370 @default.
- W1978210902 cites W2080730628 @default.
- W1978210902 cites W2081489336 @default.
- W1978210902 cites W2084403120 @default.
- W1978210902 cites W2086904982 @default.
- W1978210902 cites W2096285464 @default.
- W1978210902 cites W2100326783 @default.
- W1978210902 cites W2102161874 @default.
- W1978210902 cites W2110942360 @default.
- W1978210902 cites W2116312978 @default.
- W1978210902 cites W2117468188 @default.
- W1978210902 cites W2120482416 @default.
- W1978210902 cites W2121149321 @default.
- W1978210902 cites W2122163057 @default.
- W1978210902 cites W2124978964 @default.
- W1978210902 cites W2126353600 @default.
- W1978210902 cites W2129900247 @default.
- W1978210902 cites W2131242313 @default.
- W1978210902 cites W2136385924 @default.
- W1978210902 cites W2138270253 @default.
- W1978210902 cites W2139185517 @default.
- W1978210902 cites W2149253156 @default.
- W1978210902 cites W2149871164 @default.
- W1978210902 cites W2151300247 @default.
- W1978210902 cites W2158163463 @default.
- W1978210902 cites W2158595559 @default.
- W1978210902 cites W2167012621 @default.
- W1978210902 cites W2171247261 @default.
- W1978210902 cites W2202747550 @default.
- W1978210902 cites W2314933212 @default.
- W1978210902 cites W4301119686 @default.
- W1978210902 doi "https://doi.org/10.1091/mbc.7.7.1107" @default.
- W1978210902 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/275962" @default.
- W1978210902 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8862524" @default.
- W1978210902 hasPublicationYear "1996" @default.
- W1978210902 type Work @default.
- W1978210902 sameAs 1978210902 @default.
- W1978210902 citedByCount "48" @default.
- W1978210902 countsByYear W19782109022012 @default.
- W1978210902 countsByYear W19782109022013 @default.
- W1978210902 countsByYear W19782109022014 @default.
- W1978210902 countsByYear W19782109022015 @default.
- W1978210902 countsByYear W19782109022016 @default.
- W1978210902 countsByYear W19782109022017 @default.
- W1978210902 countsByYear W19782109022018 @default.
- W1978210902 countsByYear W19782109022019 @default.
- W1978210902 countsByYear W19782109022020 @default.