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• W1978211370 abstract "Oxalate toxicity is mediated through generation of reactive oxygen species (ROS) via a process that is partly dependent on mitochondrial dysfunction. Here, we investigated whether C-phycocyanin (CP) could protect against oxidative stress-mediated intracellular damage triggered by oxalate in MDCK cells. DCFDA, a fluorescence-based probe and hexanoyl-lysine adduct (HEL), an oxidative stress marker were used to investigate the effect of CP on oxalate-induced ROS production and membrane lipid peroxidation (LPO). The role of CP against oxalate-induced oxidative stress was studied by the evaluation of mitochondrial membrane potential by JC1 fluorescein staining, quantification of ATP synthesis and stress-induced MAP kinases (JNK/SAPK and ERK1/2). Our results revealed that oxalate-induced cells show markedly increased ROS levels and HEL protein expression that were significantly decreased following pre-treatment with CP. Further, JC1 staining showed that CP pre-treatment conferred significant protection from mitochondrial membrane permeability and increased ATP production in CP-treated cells than oxalate-alone-treated cells. In addition, CP treated cells significantly decreased the expression of phosphorylated JNK/SAPK and ERK1/2 as compared to oxalate-alone-treated cells. We concluded that CP could be used as a potential free radical-scavenging therapeutic strategy against oxidative stress-associated diseases including urolithiasis." @default.
• W1978211370 created "2016-06-24" @default.
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• W1978211370 date "2014-04-01" @default.
• W1978211370 modified "2023-10-06" @default.
• W1978211370 title "C-Phycocyanin Confers Protection against Oxalate-Mediated Oxidative Stress and Mitochondrial Dysfunctions in MDCK Cells" @default.
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• W1978211370 doi "https://doi.org/10.1371/journal.pone.0093056" @default.
• W1978211370 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3972226" @default.
• W1978211370 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24691130" @default.
• W1978211370 hasPublicationYear "2014" @default.
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