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• W1978213547 startingPage "24" @default.
• W1978213547 abstract "Dioxinodehydroeckol (DHE) isolated from Ecklonia cava, has previously been investigated for its inhibition of the differentiation of 3T3-L1 preadipocytes into adipocytes. Levels of lipid accumulation were measured, along with changes in the expression of genes and proteins associated with adipogenesis and lipolysis. Confluent 3T3-L1 preadipocytes in medium with or without different concentrations of DHE for 7 days were differentiated into adipocytes. Lipid accumulation was quantified by measuring direct triglyceride contents and Oil-Red O staining. The expression of genes and proteins associated with adipogenesis and lipolysis was measured using RT-PCR, quantitative real-time RT-PCR and Western blotting analysis. It was found that the presence of DHE significantly reduced lipid accumulation and down-regulated the expression of peroxisome proliferator-activated receptor-γ (PPARγ), sterol regulatory element-binding protein 1 (SREBP1) and CCAAT/enhancer-binding proteins (C/EBPα) in a dose-dependent manner. Moreover, DHE suppressed regulation of the adipocyte-specific gene promoters such as fatty acid binding protein (FABP4), fatty acid transport protein (FATP1), fatty acid synthase (FAS), lipoprotein lipase (LPL), acyl-CoA synthetase 1 (ACS1), leptin, perilipin and HSL compared to control adipocytes. The specific mechanism mediating the effects of DHE was confirmed by activation of phosphorylated AMP-activated protein kinase (pAMPK). Therefore, these results suggest that DHE exerts anti-adipogenic effect on adipocyte differentiation through the activation and modulation of the AMPK signaling pathway." @default.
• W1978213547 created "2016-06-24" @default.
• W1978213547 creator A5029208692 @default.
• W1978213547 creator A5037284987 @default.
• W1978213547 date "2010-06-01" @default.
• W1978213547 modified "2023-10-17" @default.
• W1978213547 title "Anti-adipogenic effect of dioxinodehydroeckol via AMPK activation in 3T3-L1 adipocytes" @default.
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• W1978213547 doi "https://doi.org/10.1016/j.cbi.2010.04.003" @default.
• W1978213547 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20385110" @default.
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