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- W1978214892 abstract "Traumatic brain injury has long been associated with abnormal coagulation parameters, but the exact mechanisms underlying this phenomenon are poorly understood. Coagulopathy after traumatic brain injury includes hypercoagulable and hypocoagulable states that can lead to secondary injury by either the induction of microthrombosis or the progression of hemorrhagic brain lesions. Multiple hypotheses have been proposed to explain this phenomenon, including the release of tissue factor, disseminated intravascular coagulation, hyperfibrinolysis, hypoperfusion with protein C activation, and platelet dysfunction. The diagnosis and management of these complex patients are difficult given the lack of understanding of the underlying mechanisms. The goal of this review is to summarize the current knowledge regarding the mechanisms of coagulopathy after blunt traumatic brain injury. The current and emerging diagnostic tools, radiological findings, treatment options, and prognosis are discussed. ABBREVIATIONS: aPC, activated protein C FFP, fresh-frozen plasma INR, international normalized ratio PT, thromboplastin time PTT, partial thromboplastin time TBI, traumatic brain injury TF, tissue factor tPA, tissue-type plasminogen activator" @default.
- W1978214892 created "2016-06-24" @default.
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- W1978214892 creator A5076261073 @default.
- W1978214892 creator A5081036923 @default.
- W1978214892 date "2012-06-01" @default.
- W1978214892 modified "2023-09-29" @default.
- W1978214892 title "Coagulopathy After Traumatic Brain Injury" @default.
- W1978214892 cites W1507312029 @default.
- W1978214892 cites W1535546167 @default.
- W1978214892 cites W1547373062 @default.
- W1978214892 cites W1555146896 @default.
- W1978214892 cites W1964095591 @default.
- W1978214892 cites W1969720423 @default.
- W1978214892 cites W1970148797 @default.
- W1978214892 cites W1970362985 @default.
- W1978214892 cites W1971209042 @default.
- W1978214892 cites W1972410117 @default.
- W1978214892 cites W1973511791 @default.
- W1978214892 cites W1974167583 @default.
- W1978214892 cites W1974329168 @default.
- W1978214892 cites W1975554781 @default.
- W1978214892 cites W1975716726 @default.
- W1978214892 cites W1975755803 @default.
- W1978214892 cites W1975824095 @default.
- W1978214892 cites W1976064306 @default.
- W1978214892 cites W1976173961 @default.
- W1978214892 cites W1976223519 @default.
- W1978214892 cites W1976283690 @default.
- W1978214892 cites W1977050755 @default.
- W1978214892 cites W1977330056 @default.
- W1978214892 cites W1979028797 @default.
- W1978214892 cites W1979790960 @default.
- W1978214892 cites W1982684770 @default.
- W1978214892 cites W1983649048 @default.
- W1978214892 cites W1984656264 @default.
- W1978214892 cites W1985500411 @default.
- W1978214892 cites W1987103866 @default.
- W1978214892 cites W1990815250 @default.
- W1978214892 cites W1991297902 @default.
- W1978214892 cites W1992034786 @default.
- W1978214892 cites W1994307317 @default.
- W1978214892 cites W1995301486 @default.
- W1978214892 cites W1996125369 @default.
- W1978214892 cites W1996528806 @default.
- W1978214892 cites W1998865265 @default.
- W1978214892 cites W1999735248 @default.
- W1978214892 cites W2001866634 @default.
- W1978214892 cites W2005599164 @default.
- W1978214892 cites W2005623034 @default.
- W1978214892 cites W2009380060 @default.
- W1978214892 cites W2010685960 @default.
- W1978214892 cites W2016207002 @default.
- W1978214892 cites W2016782581 @default.
- W1978214892 cites W2018867075 @default.
- W1978214892 cites W2019199464 @default.
- W1978214892 cites W2021556330 @default.
- W1978214892 cites W2021773314 @default.
- W1978214892 cites W2024469188 @default.
- W1978214892 cites W2025307096 @default.
- W1978214892 cites W2026580773 @default.
- W1978214892 cites W2027093124 @default.
- W1978214892 cites W2030201417 @default.
- W1978214892 cites W2030669625 @default.
- W1978214892 cites W203138372 @default.
- W1978214892 cites W2031550805 @default.
- W1978214892 cites W2032323143 @default.
- W1978214892 cites W2033924653 @default.
- W1978214892 cites W2034340681 @default.
- W1978214892 cites W2034656907 @default.
- W1978214892 cites W2035363671 @default.
- W1978214892 cites W2040177492 @default.
- W1978214892 cites W2040767898 @default.
- W1978214892 cites W2040865519 @default.
- W1978214892 cites W2041577909 @default.
- W1978214892 cites W2042784489 @default.
- W1978214892 cites W2043788887 @default.
- W1978214892 cites W2052174547 @default.
- W1978214892 cites W2053409550 @default.
- W1978214892 cites W2053577241 @default.
- W1978214892 cites W2054098408 @default.
- W1978214892 cites W2055505613 @default.
- W1978214892 cites W2058370142 @default.
- W1978214892 cites W2058563954 @default.
- W1978214892 cites W2060697119 @default.
- W1978214892 cites W206160401 @default.
- W1978214892 cites W2065955674 @default.
- W1978214892 cites W2066746471 @default.
- W1978214892 cites W2069798347 @default.
- W1978214892 cites W2071283644 @default.
- W1978214892 cites W2072043950 @default.
- W1978214892 cites W2075638893 @default.
- W1978214892 cites W2076016307 @default.
- W1978214892 cites W2076438380 @default.
- W1978214892 cites W2077967598 @default.
- W1978214892 cites W2078262133 @default.